@article{AULIFA_NOERFITRI_TRISTIYANTI_BUDIMAN_2020, title={FORMULATION OF SERUM GEL CONTAINING ANGELICA KEISKEI LEAF EXTRACT AS AN ANTIOXIDANT AND TYROSINASE ENZYME INHIBITOR}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/37303}, DOI={10.22159/ijap.2020v12i3.37303}, abstractNote={<p><strong>Objective: </strong>The aim of this study was to formulate and evaluate the efficacy of <em>Angelica keiskei</em> (AK) leaf extract in serum gel as an antioxidant and tyrosinase enzyme inhibitor.</p> <p><strong>Methods: </strong>The leaves of AK were extracted using the maceration method, while the antioxidant and tyrosinase enzyme inhibitory activities were determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and L-Tyrosine as assay and substrate, respectively. Subsequently, the extract was formulated into serum gel and evaluated for physical stability, antioxidant and inhibitory activity to tyrosinase enzyme.</p> <p><strong>Results: </strong>The results showed that AK leaf extract has antioxidant activity, with an IC<sub>50</sub> value = 7.73 mg/ml, while the tyrosinase enzyme inhibitory power had an IC<sub>50</sub> value = 500 mg/ml. Based on physical stability, the serum gel was stable after 28 d of storage. The serum gel of AK leaf extract also showed antioxidant activity and tyrosinase enzyme inhibition with IC<sub>50</sub> value of 16.68 mg/ml and 741.62 mg/ml, respectively.</p> <p><strong>Conclusion: </strong>This study demonstrated that the serum gel of AK leaf extract has potential as a skin lightening agent and is safe for use as a topical preparation.</p>}, number={3}, journal={International Journal of Applied Pharmaceutics}, author={AULIFA, DIAH LIA and NOERFITRI, RIZKA Y. and TRISTIYANTI, DEBY and BUDIMAN, ARIF}, year={2020}, month={May}, pages={108–111} }