@article{MUNDHEY_SAPKAL_DAUD_2020, title={FABRICATION OF AN ABUSE DETERRENT AND MICROEMULSION-BASED SUBLINGUAL FILM OF BUPRENORPHINE HYDROCHLORIDE FOR BREAKTHROUGH PAIN MANAGEMENT}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/38877}, DOI={10.22159/ijap.2020v12i6.38877}, abstractNote={<p><strong>Objective: </strong>The present research work aims to develop an abuse deterrent rapidly dissolving buprenorphine microemulsion loaded sublingual film for the treatment of breakthrough pain.</p> <p><strong>Methods: </strong>The Buprenorphine microemulsion loaded sublingual films were prepared using Capmul MCM C8 (oil), tween 20 (surfactant) and propylene glycol (co-surfactant) with different grades of film-forming polymer (HPMC) using film casting machine. The films were evaluated for <em>in vitro</em> disintegration and dissolution study, tensile strength, folding endurance, content uniformity, surface pH, thickness and weight variation, % loading of buprenorphine microemulsion in sublingual film, scanning electron microscope, <em>ex vivo</em> permeation study, droplet size and polydispersity index, Zeta potential, % moisture content, stability and abuse deterrent potential were evaluated.</p> <p><strong>Results: </strong>The optimized film formulation showed desired mechanical properties with minimum disintegration time of 21s and exhibited 34.45 % loading of Buprenorphine microemulsion. Permeation studies through goat sublingual mucosa, indicated 87% Buprenorphine release, through Buprenorphine microemulsion loaded sublingual film, whereas only 30% Buprenorphine release when it was directly added to film without microemulsion strategy.</p> <p><strong>Conclusion: </strong>The present study concludes that abuse deterrent and fast acting buprenorphine microemulsion-incorporated sublingual film of buprenorphine HCL and naloxone HCL is a promising alternative to mostly marketed buprenorphine injectable delivery systems and a non-invasive route of administration for breakthrough pain management.</p>}, number={6}, journal={International Journal of Applied Pharmaceutics}, author={MUNDHEY, D. and SAPKAL, N. and DAUD, A.}, year={2020}, month={Nov.}, pages={127–135} }