@article{KURNIAWANSYAH_RUSDIANA_SOPYAN_SUBARNAS_2021, title={A REVIEW ON POLOXAMER AND HYDROXY PROPYL METHYL CELLULOSE COMBINATION AS THERMORESPONSIVE POLYMERS IN NOVEL OPHTHALMIC IN SITU GEL FORMULATION AND THEIR CHARACTERIZATION}, volume={13}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/39697}, DOI={10.22159/ijap.2021v13i1.39697}, abstractNote={<p>Poor bioavailability is one of the most significant problems in the delivery of the ocular drug system. Ophthalmic ointments, solutions and suspensions are the most frequently used dosage forms to treat ocular disease, and their effectiveness as a drug are compromised by several limitations that lead to poor ocular bioavailability. <em>In situ </em>gel is one of the most promising strategy and solutions to improve the ocular bioavailability of drugs. The purpose of this review is to discuss the formulation and characterization of <em>in situ </em>gel. This review is written based on the data or information obtained by using several search engines and several scientific journals, focused on Poloxamer 407 and Hydroxy Propyl Methyl Cellulose (HPMC) bases combination.</p> <p>Active ingredients to treat ocular disease such as Ciprofloxacin, Fluconazole and Ofloxacin can be formulated with the combination of Poloxamer 407 as polymer gelling agent and HPMC as viscosity enhancer to produce good quality <em>in situ </em>gel dosage forms. The <em>in situ </em>gel dosage forms can be a promising alternate solution for the ophthalmic delivery system.</p>}, number={1}, journal={International Journal of Applied Pharmaceutics}, author={KURNIAWANSYAH, INSAN SUNAN and RUSDIANA, TAOFIK and SOPYAN, IYAN and SUBARNAS, ANAS}, year={2021}, month={Jan.}, pages={27–31} }