@article{._GOUDANAVAR_ALI_DIN WANI_SREEHARSHA_2021, title={FORMULATION AND EVALUATION OF IN-SITU GEL CONTAINING LINEZOLID IN THE TREATMENT OF PERIODONTITIS}, volume={13}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/40604}, DOI={10.22159/ijap.2021v13i3.40604}, abstractNote={<p><strong>Objective: </strong>The intent to prepare and evaluate Linezolid in-situ gel in the treatment of periodontitis.</p> <p><strong>Methods: </strong>pH-sensitive in-situ gel was formed by the cold method using a varying concentration of the drug, carbopol 934P and hydroxypropyl methylcellulose (HPMC) and carbopol 934P and sodium carboxy methylcellulose (CMC) (1:1,1:1.5,1:2,1:2.5). An optimized batch was selected based on gelling time and gelling capacity. The prepared in-situ gels were evaluated for appearance, pH, gelling capacity, viscosity, <em>in vitro</em> release studies, rheological studies, and finally, was subjected to drug content estimation and antibacterial activity test.</p> <p><strong>Results: </strong>FTIR study shows drug and physical mixture were compatible with each other. The rheology of formulated in-situ gel exhibited a pseudoplastic flow pattern. this may be because when polymer concentration was increased the prepared formulations become more viscous and in turn delayed the drug release and from the prepared formulation, LF4 and SF4 have polymer concentrations i. e, 0.9% carbopol and sodium CMC showed drug release up to 12 h<strong>. </strong></p> <p><strong>Conclusion: </strong>When carbopol is appropriately mixed with other suitable polymers it forms an in-situ gel-forming system that was substantiated by the property to transform into stiff gels when the pH is increased. The in-situ gel was prepared using a combination of carbopol-HPMC and carbopol-Na CMC The formulations LF1 to SF4 showed high linearity (R2 = 0.490-0.682), indicating that the drug was released from the prepared in-situ gel by the diffusion-controlled mechanism. Thus, the formulation of batches LF4 and SF4 containing carbopol: HPMC and carbopol: NaCMC in 1:2 ratios were considered as optimum formulation based on optimum viscosity, gelling capacity and to extend the <em>in vitro</em> drug release.</p>}, number={3}, journal={International Journal of Applied Pharmaceutics}, author={., INAYATHULLA and GOUDANAVAR, PRAKASH and ALI, MOHAMMAD and DIN WANI, SHAHID UD and SREEHARSHA, NAGARAJA}, year={2021}, month={May}, pages={79–86} }