@article{OLORUNSOLA_E. UDOH_MAJEKODUNMI_ODIONG_EBONG_2021, title={INHIBITION OF GASTRIC DEGRADATION OF OMEPRAZOLE USING A pH-SENSITIVE POLYMER AS A BINDER IN TABLET FORMULATION}, volume={13}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/41980}, DOI={10.22159/ijap.2021v13i5.41980}, abstractNote={<p><strong>Objective: </strong>This work was aimed at formulating omeprazole tablets using afzelia gum as a binder that is capable of inhibiting the gastric degradation of the drug.</p> <p><strong>Methods: </strong>Afzelia gum at different concentrations of 0, 5, 10, 15, 20 and 30% was used as a binder to formulate omeprazole tablets. The tablets were formulated by direct compression and the batches labelled F1 to F6 respectively. A batch containing 15% hydroxypropyl methylcellulose (F7) was also formulated. The tablets were characterized; and dissolution in a pH 1.2 dissolution medium over 120 min period was studied. Aliquots taken every 20 min were analyzed by ultraviolet spectrophotometry to determine the amount of drug released and not degraded.</p> <p><strong>Results: </strong>Amounts of drug released and not degraded at time 120 min were 53.1%, 57.3%, 57.8%, 58.8%, 62.1%, 83.4% and 90.0% for F1 to F7 respectively.</p> <p><strong>Conclusion: </strong>Afzelia gum at a concentration of 30% is suitable for use as a binder in tablet formulation of omeprazole to ensure substantial inhibition of gastric degradation of the drug.</p>}, number={5}, journal={International Journal of Applied Pharmaceutics}, author={OLORUNSOLA, EMMANUEL O. and E. UDOH, IMO and MAJEKODUNMI, STEPHEN O. and ODIONG, INIOBONG J. and EBONG, UWAKMFON O.}, year={2021}, month={Sep.}, pages={331–335} }