@article{GUSTAMAN_IDACAHYATI_WULANDARI_SETIAWAN_INDRA_2021, title={IMPROVEMENT OF THE DISSOLUTION PROFILE OF SIMVASTATIN TABLETS WITH THE ADDITION OF CREMOPHOR-EL USING WET GRANULATION METHOD}, volume={13}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/43869}, DOI={10.22159/ijap.2021.v13s4.43869}, abstractNote={<p><strong>Objective: </strong>Simvastatin is a drug used as a first-line anti-cholesterol in the treatment of dyslipidemia. Low solubility will affect its ability to penetrate the digestive tract membrane and will affect the amount of drug levels in the plasma. The use of Cremophor-EL as a surfactant has been shown to inhibit the action of P-glycoprotein so that it can increase the bioavailability of a drug and can increase the effect of a drug.</p> <p><strong>Methods: </strong>The preparation of simvastatin tablets was carried out using the wet granulation method. The dissolution test used the paddle method, a speed of 50 rpm at a temperature of 37±0.5 ° C with a phosphate buffer pH 7.0 as the dissolution medium.</p> <p><strong>Results: </strong>The results showed that at 30 min the generic simvastatin tablets had 81.52% dissolution and the Simvastatin Tablets with Cremophor-EL were 85.520%.</p> <p><strong>Conclusion: </strong>Simvastatin cremophor-EL tablets are more dissolved than generic simvastatin at 30 min so that cremophor-EL simvastatin tablets have a better dissolution rate than generic simvastatin tablets.</p>}, number={4}, journal={International Journal of Applied Pharmaceutics}, author={GUSTAMAN, FIRMAN and IDACAHYATI, KENI and WULANDARI, WINDA TRISNA and SETIAWAN, FAJAR and INDRA, INDRA}, year={2021}, month={Dec.}, pages={244–246} }