TY - JOUR AU - Sisinthy, Sreenivas Patro AU - Sarah, Chin Y. I. Lynn AU - Rao, Nalamolu Koteswara PY - 2016/10/01 Y2 - 2024/03/29 TI - OPTIMIZATION OF COCONUT OIL BASED SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEMS OF OLMESARTAN MEDOXOMIL BY SIMPLEX CENTROID DESIGN JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 8 IS - 4 SE - Original Article(s) DO - 10.22159/ijap.2016v8i4.14072 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/14072 SP - 47-52 AB - <p><strong>Objective: </strong>To develop and optimize self-micro emulsifying drug delivery systems of Olmesartan Medoxomil using formulation by design approach for improvement of solubility and dissolution rate.</p><p><strong>Methods: </strong>A simplex centroid design was employed as statistical tools to optimize the formulation variables, X<sub>1</sub> (Coconut oil), X<sub>2</sub> (Kolliphor RH) and X<sub>3</sub> (PEG 400). The high and low levels of these factors were selected according the micro-emulsion region obtained from the pseudo-ternary phase diagram. The response variables studied were mean globule size (Y<sub>1</sub>) and average absorbance (Y<sub>2</sub>).</p><p><strong>Results: </strong>The optimized formulation consisted of 21.54% of coconut oil, 36.04% of Kolliphor RH and 42.42% of PEG 400 which could provide a globule size of 125.94 nm and an average absorbance of 0.85. Dissolution studies revealed a marked increase in dissolution of the optimized formulation when compared with the pure drug.</p><p><strong>Conclusion: </strong>Thus, it was concluded that self-micro emulsifying drug delivery systems (SMEDDS) provided a promising formulation approach for the solubility and dissolution enhancement of the poorly soluble drug, Olmesartan Medoxomil.</p> ER -