TY - JOUR AU - Kilor, Vaishali AU - Sapkal, Nidhi AU - Daud, Anwar AU - Humne, Shruti AU - Gupta, Tushar PY - 2017/03/01 Y2 - 2024/03/28 TI - DEVELOPMENT OF STABLE NANOSUSPENSION LOADED ORAL FILMS OF GLIMEPIRIDE WITH IMPROVED BIOAVAILABILITY JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 9 IS - 2 SE - Original Article(s) DO - 10.22159/ijap.2017v9i2.16714 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/16714 SP - 28-33 AB - <p class="BodyA"><strong>Objective: </strong>In the present work attempt has been made to stabilize optimized nanosuspensions of glimepiride by solidification using a novel Oral Thin Film (OTF) formulation.</p><p class="BodyA"><strong>Methods</strong>:<strong> </strong>Nanosuspensions were characterized for particle size, zeta potential as well as <em>in vitro</em> dissolution profile. As nanosuspensions are prone to destabilization by Ostwald's ripening or agglomeration/aggregation, OTF formulation as a novel approach for stabilization through solidification of optimized nanosuspension was attempted. OTF formulation method is a simple, easy and scalable method for the preparation of solid oral dosage form. Prepared formulations were evaluated for physicochemical parameters like folding endurance, disintegration time, tensile strength, <em>in vitro</em> drug release<em>, in vivo</em> bioavailability and stability.</p><p class="BodyA"><strong>Results</strong>:<strong> </strong>The mean particle size of the nanoparticles in OTF was found to be 57.2 nm. It was observed from the results of <em>in vivo</em> bioavailability studies that high plasma drug concentrations(Cmax) were achieved for nanosuspension loaded OTF (NSOTF) i.e. 4900 ng/ml as compared to marketed oral formulation (Cmax-2900 ng/ml). Results of the stability studies indicated that nanosize of the particles was retained even after 3 mo of the study.</p><p class="BodyA"><strong>Conclusion: </strong>Therefore it can be concluded that OTF formulation has a potential for stabilization of nanosuspensions.</p> ER -