TY - JOUR AU - Sopyan, Iyan AU - Sari, Intan Mutiara AU - K., Insan Sunan PY - 2018/01/07 Y2 - 2024/03/29 TI - SOLID STATE CHARACTERIZATION OF A NOVEL PHYSICAL INTERACTION (PARACETAMOL-CHLORPHENIRAMINE MALEATE) JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 10 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2018v10i1.22840 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/22840 SP - 21-25 AB - <p><strong>Objective</strong>:<strong> </strong>Interactions of active pharmaceutical ingredients (API) as well as pharmaceutical excipients don't occur in a pharmaceutical dosage form. Base on structures of paracetamol (PCT) and chlorphenamine maleate (CTM), its combination is possible to give a physical interaction in the solid state. This study was conducted to investigate the physical interaction of PCT and CTM in the solid state.</p><p><strong>Methods: </strong>Characterization used the polarization microscope, solubility test, powder x-ray diffraction (PXRD) to observe peak shifting in 2Ɵ angle, and fourier transform infrared spectroscopy (FT-IR) to examine wavenumber shifting.</p><p><strong>Results: </strong>Results of solubility exhibited an increased solubility percentage with increasing concentration. Polarization microscope analysis presented a combination of crystal morphology after the two substances were mixed in an equimolar ratio. The result of melting point determination of each pure substance was 172 °C for PCT, 132 °C for CTM, and 170 °C for the mixture of the two substances in various ratios. Diffractogram showed the shifting at angle 2Ɵ: 20.715, 19.355-23.500 and 21.840, 26.455-20.330 for concentration ratio of PCT: CTM in (132:0.5) and (330:1) respectively and any change in the functional group was observed from infrared spectrum.</p><p><strong>Conclusion</strong>:<strong> </strong>All evaluation of PCT and CTM in the solid state has exhibited the interaction in solid condition.</p> ER -