TY - JOUR AU - Pashikanti, Shailaja AU - B., Jyothsna PY - 2019/01/07 Y2 - 2024/03/29 TI - FORMULATION AND EVALUATION OF FLOATING IN SITU GEL OF CIPROFLOXACIN JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 11 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2019v11i1.28603 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/28603 SP - 198-204 AB - <p><strong>Objective: </strong>The objective of the study was to develop floating <em>in situ</em> gel formulations of Ciprofloxacin that has a narrow absorption window and mainly absorbed in the proximal areas of GIT. These formulations increases the targeted action on bacteria for a longer time that can be used in the treatment of <em>Helicobacter pylori</em> (<em>H</em>. <em>pylori</em>) infections and urinary tract infections.<strong></strong></p><p><strong>Methods: </strong><em>In situ</em> gel formulations were prepared by varying concentrations of sodium alginate as <em>in situ</em> gel forming bio-degradable polymer and calcium carbonate as a cross-linking agent. The formulations were evaluated for Physical appearance, pH, <em>in vitro</em> drug release, viscosity, <em>in vitro</em> floating behaviour, <em>in vitro </em>gelling capacity and drug content. FTIR was conducted for Ciprofloxacin, excipients used and optimized formulation.</p><p><strong>Results: </strong>All the formulations showed an optimum viscosity that will allow ease of administration and swallowing. Floating lag time of all formulations was between 32-70 seconds and floated for&gt;12 h. The <em>in vitro</em> gelling capacity increased with increasing the polymer and gelling agent concentrations. Increase in polymer concentration decreased the rate and extent of the drug release. Among all the formulations, F4 containing 4% w/v of sodium alginate and 4% w/v of calcium carbonate showed sustained <em>in vitro</em> drug release (95.6%) over an extended period of 12 h. FTIR studies revealed no interaction between drug and excipients used. Drug release from the formulations followed First order kinetics with Fickian diffusion.</p><p><strong>Conclusion</strong>:<strong> </strong>Ciprofloxacin was successfully formulated as a pH-triggered floating <em>in situ</em> gelling system using sodium alginate.</p> ER -