TY - JOUR AU - Puspasari, Puspita AU - Saputri, Fadlina Chany PY - 2018/12/20 Y2 - 2024/03/28 TI - EFFECT OF THE WATER EXTRACT OF THE FOUR O'CLOCK HERB (MIRABILIS JALAPA L.) ON THE HEALING OF OPEN WOUNDS IN RATS JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 10 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2018.v10s1.33 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/31470 SP - 155-158 AB - <p><strong>Objective</strong>: This study aimed to analyze the effect on wound healing following treatment with a water extract of Mirabilis jalapa L. by investigating<br />wound contraction and the associated histopathological changes in rat skin.<br /><strong>Methods</strong>: Male Sprague-Dawley rats were divided into five groups, namely negative control, positive control (povidone-iodine), dose 1, dose 2, and<br />dose 3. A 20-×10-mm rectangular wound area was created for the test. In dose 1, 2, and 3 groups, the corresponding dose variation of a 0.5-mL<br />M. jalapa L. water extract (dose 1: 5% v/v, ≈243.1 mg/kg body weight BW; dose 2: 10% v/v, ≈486.2 mg/kg BW; and dose 3: 20% v/v, ≈972.4 mg/kg BW)<br />was topically applied for 14 days on open wounds of rats. Widespread wound contractions were measured on days 1, 3, 5, 7, 9, 11, and 13, and<br />histopathological changes in the skin were observed on day 15 using hematoxylin and eosin staining.<br /><strong>Results</strong>: The M. jalapa L. water extract accelerated wound healing. The optimal dose was found to be 20% v/v (≈972.4 mg/kg BW).<br /><strong>Conclusion</strong>: M. jalapa L. extracts are potential healing agents for open wounds.</p> ER -