TY - JOUR AU - IOYAH, BRENT R. AU - DJOHAN, WIDURINI AU - IDRUS, ERIK PY - 2019/04/05 Y2 - 2024/03/28 TI - EFFECT OF MANGOSTEEN PEEL EXTRACT ON BONE FRACTURE HEALING JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 11 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2019.v11s1.202 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/33383 SP - 100-102 AB - <p><strong>Objective</strong>: Healing of bone fractures is mediated through antioxidants; however, increased free radical levels at the site of fracture inhibit bone healing.<br>Mangosteen peel has antioxidant, anti-inflammatory, antitumor, antiviral, antibacterial, antifungal, antihistaminic, antimalarial, and other beneficial<br>properties as it contains many active substances such as xanthones, anthocyanins, phenols, and tannins. In this study, we aimed to determine the<br>effects of mangosteen peel extract on bone fracture healing.<br><strong>Methods</strong>: We used six mice with left and right femoral fractures (12 femurs). Mangosteen peel extract was applied to the left femurs of the six mice at<br>two dosages (20 and 40 mg/kg; three femurs each) on days 2, 4, and 6 after fracture; saline was injected into the right femurs of all six mice. On day 7,<br>all the animals were sacrificed, and femur defect diameter was evaluated using dental digital radiography.<br><strong>Results</strong>: The femoral defect diameter in mice treated with 40 mg/kg dose of mangosteen peel extract was less than that in mice treated with saline,<br>although the difference was not significant.<br><strong>Conclusion</strong>: Application of a 40 mg/kg dose of mangosteen peel extract promotes bone fracture healing.</p> ER -