TY - JOUR AU - BRINNA LISTIANI, AU - MEIDYAWATI, RATNA AU - NPA, DEWA AYU AU - ARNIAWATY, DWI PY - 2019/04/05 Y2 - 2024/03/29 TI - ANTIFUNGAL EFFICACY OF SECANG HEARTWOOD (CAESALPINIA SAPPAN L.) SOLUTIONS ON BIOFILMS OF CANDIDA ALBICANS ATCC 10231 JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 11 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2019.v11s1.16060 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/33419 SP - 160-163 AB - <p><strong>Objective</strong>: Candida albicans is a predominant fungal species found in persistent root canal infection, and its virulence depends on the ability to form<br>biofilms. To be able to eliminate this infection, a safe irrigation solution during root canal preparation is needed. This study is conducted to investigate<br>the antifungal properties of secang heartwood extract solutions on C. albicans biofilm.<br><strong>Methods</strong>: C. albicans biofilm was obtained from incubation of C. albicans ATCC 10231 at 96-well plates in 37°C for 24 h. These biofilms were exposed<br>to various treatments: Secang heartwood in three different concentrations (25%, 33%, and 50%), sodium hypochlorite (NaOCl) 2.5%, and control<br>group. The results of the treatment are to see the optical density (OD) value. The higher the OD values, the lower antifungal activity of the solution.<br><strong>Results</strong>: The mean OD result from six samples obtained the mean value of various OD values showed in ELISA reader. Antifungal efficacy of 25%<br>secang heartwood was lower than concentration of 33% and 50%. All concentrations of secang heartwood showed higher OD values than 2.5% NaOCl<br>but lower than control group with p=0.01.<br><strong>Conclusion</strong>: Secang heartwood possesses antifungal effects against C. albicans biofilm but is lower than 2.5% NaOCl. Concentration of 25% has the<br>strongest effect against C. albicans among other concentrations. This was a preliminary study of the antifungal efficacy of secang heartwood extract<br>solutions against C. albicans biofilm. The result indicates that this solution has the potential to be used as an herbal alternative in root canal irrigations.</p> ER -