TY - JOUR AU - GENATRIKA, ERZA AU - SATRIANI, FITA AU - HAPSARI, INDRI PY - 2019/09/15 Y2 - 2024/03/29 TI - ANTIBACTERIAL ACTIVITY OF CELERY LEAVES (APIUM GRAVEOLENS L.) FORMULATED IN TOOTHPASTE AGAINST STREPTOCOCCUS MUTANS JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 11 IS - 5 SE - Original Article(s) DO - 10.22159/ijap.2019.v11s5.T0028 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/35747 SP - 14-16 AB - <p><strong>Objective</strong>: The objective of this research was to determine the antibacterial activity of the toothpaste from an extract of celery leaves on Streptococcus<br>mutans.<br><strong>Methods</strong>: The toothpaste was formulated with various concentrations of celery leaves, F1 with concentration of extract (6.25%), F2 (12.5%), and<br>F3 (25%). Each formula was tested the physical characteristics and antibacterial activity toward S. mutans. The antibacterial activity was determined<br>by the agar well diffusion method using brain heart infusion agar plates. Furthermore, the antibacterial activities were assessed by the presence or<br>absence of inhibition zones after the plates were incubated at 37°C for 24 h.<br><strong>Results</strong>: The results from this test illustrate that all toothpastes under study at various concentrations of celery leaves extract exhibited antibacterial<br>activity. Maximum inhibition zone in antibacterial activity test was shown by F2 (12.5%). Therefore, we can use these toothpastes as natural<br>antibacterial on prevention of dental caries caused S. mutans.<br><strong>Conclusion</strong>: The toothpaste from an extract of celery leaves showed significant antibacterial activity against S. mutans.</p> ER -