TY - JOUR AU - SELVARAJ, GNANASEKARAN JOHN AU - BALASUBRAMANIAN, ARUL AU - RAMALINGAM, KOTHAI PY - 2020/01/15 Y2 - 2024/03/29 TI - ALTERATION OF PHARMACOKINETIC PARAMETERS OF PENTOXIFYLLINE USING NATURAL MUCOADHESIVE POLYMERS JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 12 IS - 1 SE - Short Communication(s) DO - 10.22159/ijap.2020v12i1.36080 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/36080 SP - 153-157 AB - <p><strong>Objective: </strong>The present study was aimed to alter the pharmacokinetic parameters of the drug pentoxifylline using a novel natural mucoadhesive polymer from two different plants, <em>Manilkara zapotta</em> Linn and <em>Ocimum basilicum </em>Linn.</p><p><strong>Methods: </strong>The polymer was isolated and six batches of mucoadhesive tablets of pentoxifylline was formulated with 3 different concentrations of each polymer. The best formulation from each of the polymer was selected and administered to rabbits and the plasma drug concentration was compared with the marketed formulation. The pharmacokinetic parameters such as such as C<sub>max</sub>, t<sub>max</sub>, AUC, AUMC, λ<sub>z</sub>, t<sub>1/2</sub>, and MRT were determined.</p><p><strong>Results: </strong>The plasma drug concentration vs time curve shows the extended-release of pentoxifylline when compared with the conventional marketed formulation. The results show that there is no change in the peak plasma concentration, but the significant difference was observed in t<sub>½, </sub>which showed approximately 2.5 fold increase from 2.44 to 6.87 h and the AUC showed five-fold increase from 22.40 to 117.19 μg*h/ml, and other pharmacokinetic parameters, when compared with the marketed formulation.</p><p><strong>Conclusion: </strong>The isolated polymer from the plants <em>Manilkara zapotta</em> Linn. and <em>Ocimum basilicum</em> Linn can be used as a carrier for developing mucoadhesive formulations and it alter the pharmacokinetic of pentoxifylline positively.</p> ER -