TY - JOUR AU - NICOLINE, NICOLINE AU - PARTAKUSUMA, FATIMAH BOENJAMIN AU - JOENOES, HEDIJANTI AU - TALBOT, CHRISTOPHER AU - AUERKARI, ELZA IBRAHIM PY - 2020/03/23 Y2 - 2024/03/28 TI - ASSOCIATION OF ENAM C2452T POLYMORPHISM WITH HIGH RATES OF CARIES OCCURRENCE IN AN INDONESIAN POPULATION JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 12 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2020.v12s1.14228 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/37416 SP - 1-4 AB - <p><strong>Objective</strong>: Tooth decay or the caries process is a common dental problem that affects millions of people worldwide. Many risk factors are modifiable,<br>while others are not (e.g., genetic factors). Polymorphism of the enamelin (ENAM) gene, which is required to ensure production of an essential<br>protein for enamel development, may pose as a risk factor for the caries process. This study sought to investigate the possibility of ENAM C2452T<br>polymorphism acting as a risk factor in the caries process.<br><strong>Methods</strong>: The polymerase chain reaction–restriction fragment length polymorphism method was employed to evaluate DNA samples taken from 95<br>subjects with a high caries prevalence and 89 control subjects for ENAM C2452T polymorphism.<br><strong>Results</strong>: Based on Chi-squared tests, there were significant genotype and allele distribution differences between the group with a high caries<br>prevalence and the control group (p=0.005 and p=0.007). Polymorphism in this context may, therefore, serve as a risk factor for caries onset and<br>progression (OR: 3.62).<br><strong>Conclusion</strong>: ENAM C2452T polymorphism is related to the caries process and may constitute a risk factor.</p> ER -