TY - JOUR AU - HAYATI, RAHMATUL AU - SUHARTONO, ANTONIUS WINOTO AU - MASULILI, SRI LELYATI AU - TALBOT, CHRISTOPHER AU - AUERKARI, ELZA IBRAHIM PY - 2020/03/23 Y2 - 2024/03/29 TI - ASSOCIATION BETWEEN MATRIX METALLOPROTEINASE-1 −1607 1G/2G POLYMORPHISM AND CHRONIC PERIODONTITIS IN INDONESIAN POPULATION JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 12 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2020.v12s1.ARL026 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/37419 SP - 15-17 AB - <p><strong>Objective</strong>: This study aimed to identify the distribution of matrix metalloproteinase (MMP)-1 −1607 1G/2G alleles and genotypes in subjects with<br>chronic periodontitis and healthy subjects in a sample of Indonesian population and assess the possible association of this polymorphism with<br>susceptibility to chronic periodontitis.<br><strong>Methods</strong>: Genomic DNA samples were obtained from 200 Indonesian males aged 33–78 years old, comprising 100 chronic periodontitis patients<br>and 100 healthy controls. DNA fragments were amplified by a polymerase chain reaction and analyzed by restriction fragment length polymorphism.<br>Results were analyzed by Chi-square test.<br><strong>Results</strong>: The frequency of the 2G allele was high both in subjects with periodontitis (87%) and in controls (91%). Analysis of MMP-1 genotype<br>(−1607 1G/2G) showed no significant difference between the chronic periodontitis and healthy groups (p&gt;0.05).<br><strong>Conclusion</strong>: The result found no association between MMP-1 −1607 1G/2G polymorphism and susceptibility to chronic periodontitis in Indonesian<br>subjects.</p> ER -