TY - JOUR AU - SINULINGGA, RIKA TANIA NARULITA AU - SOEROSO, YUNIARTI AU - LESSANG, ROBERT AU - SASTRADIPURA, DEWI FATMA SUNIARTI PY - 2020/07/24 Y2 - 2024/03/29 TI - PROBIOTIC LACTOBACILLUS REUTERI EFFECT’S ON THE LEVELS OF INTERLEUKIN-4 IN PERIODONTITIS PATIENTS AFTER SCALING AND ROOT PLANING JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 12 IS - 2 SE - Original Article(s) DO - 10.22159/ijap.2020.v12s2.PP-20 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/39204 SP - 64-68 AB - <p><strong>Objective</strong>: Periodontal disease is an inflammatory disease principally caused by a complex interaction between pathogenic bacteria and immune<br>responses. Probiotics stimulate the immune system of the oral mucosa by increasing the production of anti-inflammatory cytokines. Interleukin-4 (IL-4) is<br>the anti-inflammatory cytokine that is most closely associated with the pathogenesis of periodontitis. This study assessed the effect of Lactobacillus reuteri<br>(L. reuteri) containing probiotic lozenges toward clinical attachment loss (CAL) and IL-4 levels in periodontitis patients after scaling and root planing.<br><strong>Materials and Methods:</strong> Clinical samples were collected from the gingival crevicular fluid of 16 periodontitis patients with pocket depth (PD) of<br>6 mm. The samples were divided into two groups. The non-probiotic group included periodontitis patients treated through scaling and root planing<br>(SRP) only (n=8), whereas the probiotic group included periodontitis patients treated through SRP and probiotics (n=8). The measurements of the<br>clinical parameters of PD and CAL were included as diagnostic criteria. Probiotic lozenges were given daily for 14 days. IL-4 levels were measured in<br>both groups using the enzyme-linked immunosorbent assay (ELISA) method.<br><strong>Results</strong>: IL-4 levels decreased in the non-probiotic group and increased in the probiotic group, but there was no statistical difference between the<br>groups. CAL decreased in both groups and was significantly different.<br><strong>Conclusion</strong>: SRP with the consumption of probiotic-containing L.reuteri in periodontitis patients resulted in decreased CAL and increased IL-4 levels<br>compared with SRP only.</p> ER -