TY - JOUR AU - PERTIWI, DEWI AU - HAFIZ, IHSANUL AU - JANNAH, WARDATUL AU - WINATA, HANAFIS SASTRA AU - SARI, MELIA AU - SUROYO, RAZIA BEGUM PY - 2020/11/07 Y2 - 2024/03/29 TI - ANTIBACTERIAL ACTIVITIES OF BELIMBING WULUH (AVERRHOA BILIMBI L.) ETHYL ACETATE EXTRACT ON GEL FORMULATED AGAINST PROPIONIBACTERIUM ACNES AND STAPHYLOCOCCUS AUREUS JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 12 IS - 6 SE - Original Article(s) DO - 10.22159/ijap.2020v12i6.39406 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/39406 SP - 224-228 AB - <p><strong>Objective: </strong><em>Averrhoa bilimbi</em> is a plant that is used as a food spice and traditional medicine in Indonesia. The purpose of this study was to obtain a gel formula and measure its activity in inhibiting the growth of skin bacteria, namely Propionibacterium acnes and Staphylococcus aureus.</p><p><strong>Methods: </strong>The gel formulation was tested organoleptically, homogeneity, pH, dispersibility test, and skin irritation test. Antibacterial activity test using agar diffusion method, inhibition of bacterial growth was compared with clindamycin as a positive control.</p><p><strong>Results: </strong>All gel formulations showed good homogeneity, pH of the preparations ranged from 4.5 to 6.1, the dispersion test was 5.5-6.5 cm, and none of them caused irritation to the skin. The results of the inhibitory activity against the growth of <em>Propionibacterium acnes</em> bacteria on concentrations 10, 15, and 20% were 16.67 + 0.40, 22.70 + 0.32 and 28.10 + 0.36 and <em>Staphylococcus aureus</em> bacteria were 18.53 + 0.22, 24.16 + 0.29 and 30.40 + 0.4. &nbsp;The inhibitory activity of clindamycin against <em>Propionibacterium acnes</em> and <em>Staphylococcus aureus bacteria</em> were 35.33+0.29 and 36.30+0.37.</p><p><strong>Conclusion: </strong>Ethyl acetate extract gel <em>Averrhoa bilimbi</em> had good activity in inhibiting the growth of <em>Propionibacterium acnes</em> and <em>Staphylococcus aureus</em> bacteria and has the potential to be used as an herbal anti-acne drug.</p> ER -