TY - JOUR AU - S. H., GIRISH AU - C., SURABHI AU - P., SATHISH BABU AU - S., MEENAKSHI AU - SIDDARAMAIAH, AU - K. S., NITHIN AU - GOWDA, D. V. PY - 2021/03/07 Y2 - 2024/03/28 TI - FORMULATION AND EVALUATION OF SOLID SELF MICRO EMULSIFYING DISPERSIBLE TABLET OF PIROXICAM JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 13 IS - 2 SE - Original Article(s) DO - 10.22159/ijap.2021v13i2.40238 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/40238 SP - 127-133 AB - <p><strong>Objective: </strong>The aim of this study was to formulate the solid self-micro emulsifying dispersible tablets for promoting the dissolution of Piroxicam.</p><p><strong>Methods: </strong>Solubility study test was performed to know the solubility of various oil phase, surfactants, cosurfactants. Self-emulsifying grading test was done by visual grading system. Ternary phase diagrams and droplet size analysis test were performed to screen and optimize the Piroxicam-self microemulsifying drug delivery system (SMEDS). Then microcrystalline cellulose (KG802) was added as a suitable adsorbent and dispersible tablet were prepared by wet granulation compression method.</p><p><strong>Results: </strong>The final composition of Piroxicam-SMEDS was oil phase (oleic acid, 23%), surfactant (Cremophor R H-40,61%), co-surfactant (PEG-400,16%) based on the result of solubility test, self-emulsifying grading test, droplet size analysis and ternary phase diagrams. Microcrystalline cellulose (KG802) was selected based on dissolution study (98.35%) and added to liquid Piroxicam-Smeds formulation to form dispersible tablets. The <em>in vitro </em>dissolution study showed 98.02 % of drug release from Piroxicam-SMEDS tablets.</p><p><strong>Conclusion: </strong>Piroxicam–Self microemulsifying dispersible tablets have increased the solubility and bioavailability of the Piroxicam to a greater extent. SMEDS formulation can help the solubility of poorly water-soluble drugs. </p> ER -