TY - JOUR AU - SAIFEE, BATUL AU - SONI, PRAKASH K. AU - PASWAN, SURESH K. AU - SAINI, T. R. PY - 2021/05/07 Y2 - 2024/03/29 TI - FORMULATION AND OPTIMIZATION OF NATURAL GUM BASED EXTENDED RELEASE TABLETS OF LOSARTAN USING D-OPTIMAL MIXTURE DESIGN JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 13 IS - 3 SE - Original Article(s) DO - 10.22159/ijap.2021v13i3.40702 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/40702 SP - 214-220 AB - <p><strong>Objective: </strong>Losartan potassium is one of the widely prescribed antihypertensive drugs administered orally and its extended-release tablet formulations are essentially required for the long-acting effect at reduced dosage frequency. The present research was aimed for the development and optimization of an extended-release tablet of losartan potassium, exploring natural gums, i.e., xanthan gum and guar gum as drug release modifiers.</p><p><strong>Methods: </strong>The tablet formulation was prepared by wet granulation method and the formulation optimization was done by D-optimal mixture design using Design Expert<sup>®</sup> software. The independent variables studied were xanthan gum (X<sub>1</sub>), guar gum (X<sub>2</sub>) and lactose (X<sub>3</sub>) taking various combinations of the total amount of gum and ratio of xanthan gum to guar gum under the given constraint range. The dependent (response) variables studied were % drug release in 1h (Y<sub>1</sub>), 4h (Y<sub>2</sub>), 7h (Y<sub>3</sub>) and 10h (Y<sub>4</sub>). The developed tablets were evaluated for physical properties, i.e., hardness, friability, weight variation as well as the <em>in vitro</em> drug release profiles. For optimization studies, the polynomial equations and response surface plots were generated and the optimized formulation was selected on the basis of maximum desirability value.</p><p><strong>Results: </strong>The developed tablet formulation was found to possess all physical properties within the desired range and showed sustained release profile with <strong>~</strong>80% drug release in 10 h duration. The model fitting studies demonstrated best fit in the zero-order model and the slope value of Korsmeyer–Peppas plot was ˃0.89, suggesting case II transport as a drug release mechanism.</p><p><strong>Conclusion: </strong>The findings suggested that natural gums-based matrix tablets of losartan could be successfully developed and natural gums can be explored as platform technology as release retardants and in the development of sustained-release matrix tablets of other drugs.</p> ER -