TY - JOUR AU - FALYA, YUNIARTI AU - AMELIA, RENNY AU - RIZIKIYAN, YAYAN AU - SULASTRI, LELA AU - HIDAYATI, NUR RAHMI PY - 2022/11/26 Y2 - 2024/03/29 TI - DISCOVERING TYROSINASE INHIBITORS FROM MORUS SP. PLANTS: AN IN SILICO STUDY JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 14 IS - 4 SE - Original Article(s) DO - 10.22159/ijap.2022.v14s4.PP30 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/46934 SP - 126-130 AB - <p><strong>Objective: </strong>This study aimed to examine <em>Morus sp.</em> compounds bonding mode with critical amino acid residues in the binding pocket of the enzyme TRP1 in <em>In silico</em> so that it can be used as a support in the design of skin-lightening cosmetics based on <em>Morus</em> <em>sp.</em></p><p><strong>Methods: </strong>Docking is done using autodock tools software, chem office 2019, ChemDraw professional 12, autodock 4.2, discovery studio 2016.</p><p><strong>Results: </strong>Isorhamnetin has two hydrogen bonds to amino acids Met215 and Asn205. Other compounds found in <em>Morus sp.</em>, which have hydrogen bonds with Asn205, are dihydromorin, kaempferol, quercitrin, rutin, and morusin.</p><p><strong>Conclusion: </strong>Isorhamnetin has the best potential among other compounds as a tyrosinase inhibitor by hydrogen binding to the amino acid Met215, and Asn205 has a free energy of-6.16 kcal/mol.</p> ER -