TY - JOUR AU - S., SUKMAWATI AU - MUSFIROH, IDA AU - MUCHTARIDI, AU - FRISTIOHADY, ADRYAN PY - 2022/12/27 Y2 - 2024/03/29 TI - QUST AL HINDI (SAUSSUREA LAPPA): A NARRATIVE REVIEW OF ITS PHYTOCHEMISTRY AND PHARMACOLOGICAL POTENTIAL AGAINST COVID-19 JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 14 IS - 5 SE - Review Article(s) DO - 10.22159/ijap.2022.v14s5.17 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/47156 SP - 1-7 AB - <p>In 2020, the World Health Organization officially designated Coronavirus Disease 2019 (COVID-19) to be global pandemic. Response of immune to SARS-CoV-2 infection includes a hyper-inflammatory state. <em>Saussurea lappa </em>is a medical plant known in several traditional medical systems, such as Persian and Indian medicine. <em>S. lappa </em>has anticancer, antiviral, antirheumatic, anti-inflammatory, and hepatoprotective properties as clinically demonstrated. The purpose of this article to analyze the content of chemical compounds and possible pharmacological activities to fight COVID-19. As primary data sources for this study, researchers looked at articles about the possibility of <em>Saussurea lappa</em> as an alternative in the treatment of COVID-19. Data were gathered online through various academic papers published from 2012 to 2022 derived from the PubMed and Google Scholar databases.</p><p>One of the components of <em>Saussurea lappa</em> is myrcene which might act on ACE receptors. SARS-CoV-2 enters cells via endocytosis after binding to the ACE2 receptor. The anti-inflammatory properties of <em>Saussurea lappa</em> can be used to treat COVID-19 by reducing inflammatory cytokinins (TNF-α, IL-1β). Further study and clinical trials are needed to prove the effectiveness of <em>Saussurea lappa</em> against COVID-19 patients. <em>Saussurea lappa </em>has a important role in treating COVID-19 based on the effects of active phytochemical compounds that have anti-inflammatory activity, antioxidant, immunomodulator, antcancer, antihepatotoxic, and antihipertension. The <em>Qust al Hindi</em> has not yet been a final drug for the treatment of COVID-19 for it must go through clinical trials on COVID-19 patients directly.</p> ER -