Healing Effect of Propolis in Medicine and Dentistry: A review

Himanshu Deswal, Yogender Singh, Harpreet Singh Grover, Amit Bhardwaj


Propolis is a natural product derived from plant resins collected by honeybees. Propolis has maintained its popularity over a long period of time.  The pharmacologically active molecules are flavonoids, phenolic acids, and their esters. Propolis has a degree of anti microbial action against fungi such as Candida Albicans and some bacteria including a range of oral micro organisms and viruses and may be as effective as acyclovir against herpes simplex virus. In addition, propolis and its components have anti-inflammatory, immunomodulatory activities, and antitumor activity. In dentistry, Propolis has been used in dentifrices, as a storage medium for teeth that have avulsed, in periodontal therapy . Its use in canal debridement for endodontic procedures has been explored. Because of its strong, anti-infective activity, propolis has often been called a “natural antibiotic.” Many studies show its strong inhibitory effect on a wide variety of pathogenic organisms.Propolis extract used as mouth rinse procure  anti microbial activity against streptococcus mutans present in the oral cavity. Subgingival irrigation with Propolis extract as an adjunct to periodontal treatment may also be more effective than scaling and root planning alone. Propolis extract possesses anti-plaque activity and improves gingival health. The extract might be used as an alternative measure to prevent periodontal and gingival problems.It has promising role in future medicine as well as dentistry.

| PDF |


Rathod S, Brahmankar R, Kolte A. Propolis - A natural remedy. Indian Journal of Dental Research And Review 2012;1:50-2.

Dodwad V, Kukreja BJ. Propolis mouthwash: A new beginning. J Indian Soc Periodontol 2011;15:121-5.

Parolia A, Thomas MS, Kundabala M, Mohan M. Propolis and its potential uses in oral health . Int J Med Med Sci 2010;2:210-5.

Park YK, Alencar SM, Aguiar CL. Botanical origin and chemical composition of Brazilian propolis. J Agric Food Chem 2002;50:2502-6.

Bankova V. Recent trends and important developments in propolis research Evid Based Complement Alternat Med 2005;2:29–32.

Lotfy M. Biological Activity of Bee Propolis in Health and Disease. Asian Pac J Cancer Prev 2006;7:22-31.

J M Grange, R W Davey. Antibacterial properties of propolis (bee glue). J R Soc Med 1990;83:159–60.

Aga H, Shibuya T, Sugimoto T, Kurimoto M, Nakajima S. Isolation and identification of antimicrobial compounds in Brazilian Propolis. Bioscience Biotechnology and Biochemistry 1994;58:945-6.

Amoros M, Lurton E, Boustie J, Girre L, Sauvager F, Cormier M.Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate. J Nat Prod 1994;57:644-7.

Serkedjieva J, Manolova N, Bankova V. Anti-influenza virus effect of some propolis constituents and their analogues (esters of substituted cinnamic acids). J Nat Prod 1992;55:294-302.

Ota C, Unterkircher C, Fantinato V, Shimizu MT. Antifungal activity of propolis on different species of Candida. Mycoses 2001;44:375-8.

de Castro SL, Higashi KO. Effect of different formulations of propolis on mice infected with Trypanosoma cruzi. J Ethnopharmacol 1995;46:55-8.

Park EH, Kahng JH. Suppressive effects of propolis in rat adjuvant arthritis. Arch Pharm Res 1999;22:554-8.

Kimoto T, Arai S, Kohguchi M, Aga M, Nomura Y, Micallef MJ, et al. Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis. Cancer Detect Prev 1998;22:506-15.

Luo J, Soh JW, Xing WQ, Mao Y, Matsuno T, Weinstein IB. PM-3, a benzo-gamma-pyran derivative isolated from propolis, inhibits growth of MCF-7 human breast cancer cells. Anticancer Res 2001;21:1665-71.

Irmak MK, Fadillioglu E, Sogut S, Erdogan H, Gulec M, Ozer M, et al. Effects of caffeic acid phenethyl ester and alpha-tocopherol on reperfusion injury in rat brain. Cell Biochem Funct 2003;21:283-9.

Magro-Filho O, de Carvalho AC. Topical effect of propolis in the repair of sulcoplasties by the modified Kazanjian technique. Cytological and clinical evaluation. J Nihon Univ Sch Dent 1994;36:102-11.

Magro Filho O, de Carvalho AC. Application of propolis to dental sockets and skin wounds. J Nihon Univ Sch Dent 1990;32:4-13.

Gopikrishna V, Baweja PS, Venkateshbabu N, Thomas T, Kandaswamy D. Comparison of coconut water, propolis, HBSS, and milk on PDL cell survival. J Endod 2008;34:587-9.

Al-Qathami H, Al-Madi E. Comparison of sodium hypochlorite, propolis and salineas root canal irrigants: A pilot study. Saud Dent J 2003;5:100-3.

Fatih Özan, Zeynep Sümer, Zübeyde Akın Polat, Kürşat Er, Ülkü Özan, Orhan Deger. Effect of Mouthrinse Containing Propolis on Oral Microorganisms and Human Gingival Fibroblasts. Eur J Dent 2007;1:195–201.

Hayacibara MF, Koo H, Rosalen PL, Duarte S, Franco EM, Bowen WH, et al. In vitro and in vivo effects of isolated fractions of Brazilian propolis on caries development. J Ethnopharmacol 2005;101:110-5.

Almas K, Mahmoud A, Dahlan A. A comparative study of propolis and saline application on human dentin. A SEM study. Indian J Dent Res 2001;12:21-7.

Toker H, Ozan F, Ozer H, Ozdemir H, Eren K, Yeler H. A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats. J Periodontol 2008;79:1089-94.

Santos VR, Gomes RT, de Mesquita RA, de Moura MD, França EC, de Aguiar EG et al. Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytother Res 2008;22:1544-7.

Awawdeh L, Al-Beitawi M, Hammad M. Effectiveness of propolis and calcium hydroxide as a short-term intracanal medicament against Enterococcus faecalis: a laboratory study. Aust Endod J 2009;35:52-8.

Samet N, Laurent C, Susarla SM, Samet-Rubinsteen N. The effect of bee propolis on recurrent aphthous stomatitis: a pilot study. Clin Oral Investig 2007;11:143-7.

About this article


Healing Effect of Propolis in Medicine and Dentistry: A review



Additional Links

Manuscript Submission


Innovare Journal of Ayurvedic Sciences
Vol 4 Issue 2 2016 ( April - May) Page: 1-4

Online ISSN


Authors & Affiliations

Himanshu Deswal
PG Student, Department of Periodontology, Faculty of Dental Sciences, SGT University, Gurgaon.

Yogender Singh
PG Student, Department of Periodontology, Faculty of Dental Sciences, SGT University, Gurgaon.

Harpreet Singh Grover
Prof.& Head,Department of Periodontology,Faculty of Dental Sciences,SGT University,Gurgaon.

Amit Bhardwaj
Reader,Department of Periodontology,Faculty of Dental Sciences,SGT University,Gurgaon.

Article Tools


  • There are currently no refbacks.