PROTECTIVE EFFECT OF ACORUS CALAMUS RHIZOME IN PARACETAMOL EXPOSURE INDUCED HEPATOTOXICITY IN RATS :BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY

  • Gullapudi Sri Vidya Sri Venkateswara Veterinary University, Tirupati

Abstract

Abstract

Objective: To study the hepatoprotective activity of aqueous and alcoholic extract of Acorus calamus rhizomes against the paracetamol induced hepatotoxicity in rats

Methods: Hepatotoxicity was induced by oral administration of paracetamol and chemical parameters such as Glutathione peroxidase, Glutathione reductase, Glutathione, Catalase , lipid peroxidation and histopathological changes in liver was studied by comparing with Silymarin, a standard hepatoprotective drug

Results: Treatment of rats with aqueous and alcoholic extract of Acoruscalamus rhizome after paracetamol administration normalized the altered levels of above parameters which may comparable with Silymarin and Vit-E. The hepatoprotective activity was confirmed by histopathological examination of the liver tissue of control and treated animals.

Conclusion: Based on the result it can be concluded that Acorus calamus rhizome possesses hepatoprotective effect against paracetamol induced hepatotoxicity in rats

KEYWORDS:  Acorus calamus rhizome, Paracetamol, Silymarin,Vit-E,Hepatoprotection

 

Author Biography

Gullapudi Sri Vidya, Sri Venkateswara Veterinary University, Tirupati
Assistant Professor,
Dept. of Veterinary Pharmacology and Toxicology, 
N.T.R. College of Veterinary Science, 
Gannavaram, Krishna, Andhra Pradesh,
India-521102
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How to Cite
Vidya, G. S. (2017). PROTECTIVE EFFECT OF ACORUS CALAMUS RHIZOME IN PARACETAMOL EXPOSURE INDUCED HEPATOTOXICITY IN RATS :BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY. Innovare Journal of Ayurvedic Sciences, 10(3). Retrieved from https://innovareacademics.in/journals/index.php/ijas/article/view/18728
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Original Article(s)