PROTECTIVE EFFECT OF ACORUS CALAMUS RHIZOME IN PARACETAMOL EXPOSURE INDUCED HEPATOTOXICITY IN RATS :BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY

Abstract

Abstract

Objective: To study the hepatoprotective activity of aqueous and alcoholic extract of Acorus calamus rhizomes against the paracetamol induced hepatotoxicity in rats

Methods: Hepatotoxicity was induced by oral administration of paracetamol and chemical parameters such as Glutathione peroxidase, Glutathione reductase, Glutathione, Catalase , lipid peroxidation and histopathological changes in liver was studied by comparing with Silymarin, a standard hepatoprotective drug

Results: Treatment of rats with aqueous and alcoholic extract of Acoruscalamus rhizome after paracetamol administration normalized the altered levels of above parameters which may comparable with Silymarin and Vit-E. The hepatoprotective activity was confirmed by histopathological examination of the liver tissue of control and treated animals.

Conclusion: Based on the result it can be concluded that Acorus calamus rhizome possesses hepatoprotective effect against paracetamol induced hepatotoxicity in rats

KEYWORDS:  Acorus calamus rhizome, Paracetamol, Silymarin,Vit-E,Hepatoprotection