TY - JOUR AU - MIJANUR, RAHMAN AU - SHAHDA, HOSSAIN PY - 2013/04/01 Y2 - 2024/03/28 TI - CENTELLA ASIATICA (LINN.) URBAN AMELIORATES OXIDATIVE STRESS ON ERYTHROCYTE MEMBRANE JF - Innovare Journal of Ayurvedic Sciences JA - Innovare J Ay Sci VL - 1 IS - 1 SE - Articles DO - UR - https://journals.innovareacademics.in/index.php/ijas/article/view/22 SP - 1-4 AB - <p>The effect of <em>Centella asiatica </em>on erythrocyte membrane under normal and oxidative stressed condition was investigated in the present study. 100% ethanol, 50% ethanol and water extract of <em>Centella asiatica</em> were screened for in vivo study by in vitro hypotonia-induced and time dependant H<sub>2</sub>O<sub>2</sub>-induced antihemolytic activity assay. During in vivo study, test group rats (n=7) were orally administered with 50% ethanol extract of <em>Centella asiatica</em> at a dose of 250 mg/kg/day for 6 weeks while control group rats were administered with normal saline. Then, levels of lipid peroxide (LPO) of erythrocyte ghost membrane from control and test group rats were estimated under normal and in vitro H<sub>2</sub>O<sub>2</sub>-induced oxidative stressed condition. All of the three extract prevent hypotonic solution induced hemolysis while 50% ethanol extract showed highest H<sub>2</sub>O<sub>2</sub>-induced antihemolytic activity in a time dependant manner. The LPO levels of the erythrocyte ghost membrane under H<sub>2</sub>O<sub>2</sub>-induced oxidative stressed condition were significantly decreased as a result of <em>C. asiatica</em> administration but not in normal condition. Therefore, the extract of <em>C. asiatica</em> has the ability to ameliorate oxidative stress on erythrocytes membrane at least upon oxidative challenge.</p> ER -