FORMULATION AND EVALUATION OF FLOATING BEADS OF DILTIAZEM HCL

  • Shivendra Agarwal Agarwal Vivek College of Technical Education, Bijnor, 246701 (U. P) India
  • Faraz Zamil
  • Lokendra Singh
  • Amit Saxena

Abstract

Objective: Diltiazem, a benzothiazepine calcium channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. The elimination half-life of Diltiazem is 3 to 4.5 h. In the present research work multiple units floating drug delivery systems of Diltiazem Hydrochloride were prepared by using sodium alginate, mustard oil and olive oil.

Methods: The floating systems were prepared by using emulsion gelation technique to improve gastric retention. The prepared beads were evaluated for physical characterization floating lag time, total floating time, swelling index and in vitro drug release studies. The prepared beads were found to be spherical, free flowing and remain buoyant for 24 h with a short floating lag time.

Results: Percentage drug content of beads in the formulation F9 For olive oil and H8 for mustard oil was found to be in the range of 95.89 to 54.08%. Swelling properties of all formulation increased as the concentration of SCMC increased. The particle size increased as the amount of polymer was increased in each formulation.

Conclusion: Floating beads of Diltiazem HCL could prompt a potential sustained drug delivery over an extend period of time that can reduce dose frequency. It was also found that the cumulative drug release from all formulations was found to be between 94.93 to 100.042.

Keywords: Beads, Diltiazem HCL, Sodium alginate, Calcium chloride, Olive Oil

 

References

1. Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery system. Expert Opin Drug Delivery 2006;3:217-33.
2. Iannucelli V, Coppi G, Bernabei MT, Camerorni R. Air compertment multiple-unit system for prolonged gastric residence Part-I. Formulation study. Int J Pharm Sci 1998;174:47-54.
3. Garg R, Gupta GD. Progress in controlled gastro retentive delivery systems. Trop J Pharm Res 2008;7:1055-66.
4. Ferna´ndez-Herva´s MJ, Holgado MA, Fini A, Fell JT. In vitro evaluation of alginate beads of a diclofenac salt. Int J Pharm Sci 1998;163:23–34.
5. Choudhury PK, Kar M. Preparation of alginate gel beads containing metformin hydrochloride using emulsion–gelation method. Tropical J Pharm Res 2005;4:489–93.
6. Clarke GM, Newton JM, Short MD. Comparative gastrointestinal transit of pellet systems of varying density. Int J Pharm Sci 1995;114:1-11.
7. British Pharmacopoeia. The controller of her majesty’s stationary office, Council of Europe, London; 2001;1;1103.
8. Gaur RS, Gupta GD. A practical physical pharmacy. 9th edtn. CBS Publishers and Distributers PVT. LTD; 2011.
9. Indian Pharmacopoeia. The government of India, Ministry of Health and Family welfare, Controller of Publications, New Delhi; 1996. p. 634-5.
10. Goyal MK, Mehta SC. Preparation and evaluation of calcium silicate based floating beads of amoxicillin. J Appl Pharm Sci 2011;1:137-41.
11. Gergogiannis YS, Rekkas DM, Dallos PP, Chailis NH. Floating and swelling characteristics of various excipients used in controlled release technology. Drug Dev Ind Pharm 1993;19:1061‐81.
12. Singhvi G, Singh M. Review in vitro drug release characterization models. Int J Pharm Studies Res 2011;2:77-84.
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How to Cite
Agarwal, S. A., F. Zamil, L. Singh, and A. Saxena. “FORMULATION AND EVALUATION OF FLOATING BEADS OF DILTIAZEM HCL”. International Journal of Current Pharmaceutical Research, Vol. 8, no. 3, July 2016, pp. 38-42, https://innovareacademics.in/journals/index.php/ijcpr/article/view/13246.
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Original Article(s)