FORMULATION AND EVALUATION OF FLOATING BEADS OF DILTIAZEM HCL


Shivendra Agarwal Agarwal, Faraz Zamil, Lokendra Singh, Amit Saxena

Abstract


Objective: Diltiazem, a benzothiazepine calcium channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. The elimination half-life of Diltiazem is 3 to 4.5 h. In the present research work multiple units floating drug delivery systems of Diltiazem Hydrochloride were prepared by using sodium alginate, mustard oil and olive oil.

Methods: The floating systems were prepared by using emulsion gelation technique to improve gastric retention. The prepared beads were evaluated for physical characterization floating lag time, total floating time, swelling index and in vitro drug release studies. The prepared beads were found to be spherical, free flowing and remain buoyant for 24 h with a short floating lag time.

Results: Percentage drug content of beads in the formulation F9 For olive oil and H8 for mustard oil was found to be in the range of 95.89 to 54.08%. Swelling properties of all formulation increased as the concentration of SCMC increased. The particle size increased as the amount of polymer was increased in each formulation.

Conclusion: Floating beads of Diltiazem HCL could prompt a potential sustained drug delivery over an extend period of time that can reduce dose frequency. It was also found that the cumulative drug release from all formulations was found to be between 94.93 to 100.042.

Keywords: Beads, Diltiazem HCL, Sodium alginate, Calcium chloride, Olive Oil

 


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About this article

Title

FORMULATION AND EVALUATION OF FLOATING BEADS OF DILTIAZEM HCL

Date

01-07-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 3, 2016 Page: 38-42

Online ISSN

0975-7066

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80 Views | 222 Downloads

Authors & Affiliations

Shivendra Agarwal Agarwal
Vivek College of Technical Education, Bijnor, 246701 (U. P) India

Faraz Zamil

Lokendra Singh

Amit Saxena


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