ANTI-ATHEROSCLEROTIC AND LIPID LOWERING EFFECTS OF CINNAMOMUM VERUM IN CHOLESTEROL-FED RABBITS


Suresh C. Joshi, Pratibha K. Jain, Priyanka Sharma

Abstract


Objective: The present study was designed to investigate the antihyperlipidemic and anti-atherosclerotic activity of 70% methanolic crude extract of Cinnamomum verum bark in high cholesterol-fed diet rabbits.

Methods: C. verum extract was administered at a dose level of 200 mg/kg and 300 mg/kg (p. o) daily for 120 d to cholesterol-fed rabbits. Lipid profile in serum and histological changes in heart and aorta were investigated. The statistical analysis was carried out by student’s ‘t’test.

Results: Plant extract showed a significant decrease in the levels of serum total cholesterol, triglycerides, phospholipids, LDL, VLDL (P ≤ 0.001) in a dose-dependent manner in treated animals. HDL ratio improved overwhelmingly as well as the marked decline was also noticed in the atherogenic index after administration with C. verum extract. Histopathological examinations demonstrated less cholesterol deposits in the aorta and significant increase in lumen size of coronary arteries of high cholesterol diet animals given C. verum compared to the high cholesterol diet animals not given C. verum supplement.

Conclusion: The phytochemical analysis of methanol extracts indicated a strong presence of alkaloids, flavonoids, tannins, phenols, saponins and fatty acids may be responsible for the significant hypolipidaemic as well as antiatherosclerotic activity. Our study exhibited that the methanol extract of C. verum bark is a potent hypolipidaemic agent and decreased cholesterol deposition in the aorta and plaque formation process in the coronary artery of high cholesterol diet animals.


Keywords


Cinnamomum verum, Atherosclerosis, Hyperlipidaemic, Phytoconstituents, Cholesterol, Methanolic extract

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About this article

Title

ANTI-ATHEROSCLEROTIC AND LIPID LOWERING EFFECTS OF CINNAMOMUM VERUM IN CHOLESTEROL-FED RABBITS

Keywords

Cinnamomum verum, Atherosclerosis, Hyperlipidaemic, Phytoconstituents, Cholesterol, Methanolic extract

DOI

10.22159/ijcpr.2017v9i1.16618

Date

31-12-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 1, 2017 Page: 75-80

Online ISSN

0975-7066

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Authors & Affiliations

Suresh C. Joshi
Reproductive Toxicology Unit, Center for advanced studies, Department of Zoology, University of Rajasthan, Jaipur 302055 India

Pratibha K. Jain
Reproductive Toxicology Unit, Center for advanced studies, Department of Zoology, University of Rajasthan, Jaipur 302055 India

Priyanka Sharma
Reproductive Toxicology Unit, Center for advanced studies, Department of Zoology, University of Rajasthan, Jaipur 302055 India


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