EMULGEL: A NEW APPROACH FOR ENHANCED TOPICAL DRUG DELIVERY


Sunil Kumar Yadav, Manoj Kumar Mishra, Anupamaa Tiwari, Ashutosh Shukla

Abstract


Emulgel is used to treat aches and pains caused by colds, headaches, muscle aches, backaches, arthritis and other conditions and injuries. The patient adherence to topical formulations is significant in relation to chronic skin diseases, like fungal infections, acne, psoriasis. Emulgel is one of the recent technology in NDDS used topically having characteristics of dual control release i.e. emulsion as well as gel. Emulgels have emerged as one of the most interesting topical delivery systems as it has dual release control system i.e. gel and emulsion. When gel and emulsion are used in combined form, the dosage form are referred as emulgel.

Keywords


Emulgel, Gelling agents, Topical drug delivery, Skin diseases

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References


Kullar R, Saini S, Steth N, Rana AC. Emulgel a surrogate approach for topical used hydrophobic drugs. Int J Pharm Biol Sci 2011;1:117-28.

Single V, Saini S, Joshi B, Rana AC. Emulgel: a new platform for topical drug delivery. Int J Pharm Biol Sci 2012;3:485-98.

Stan-Posthuma JJ, Vink J, Le Cessie S, Bruijn JA, Bergman W, Pavel S. Topical tretinoin under occlusion on a typical navei. Asian J Pharm Clin Res 1998;8:539-48.

Mohamed MI. Optimization of chlorphenesin emugel formulation. AAPS J 2004;6:81-7.

Mishra AN. Controlled and novel drug delivery. 4th ed. CBS Publisher and Distributers, Delhi; 1997. p. 107-9.

Swarbrick J. Encyclopedia of pharmaceutical technology. 3rd ed. Vol. 1. Informa Healthcare; 2007. p. 1311-23.

Cecv G, Mazgareanu S, Rother M. Preclinical characterisation of NSAIDs in ultra deformable carriers or conventional topical gels. Int J Pharm 2008;360:29-39.

Kalia YN, Guy RH. Modeling transdermal drug release. Adv Drug Delivery Rev 2001;48:159-72.

Ayub AC, Gomes AD, Lima MV, Vianna-Soares CD, Ferreira LA. Topical delivery of fluconazole: in vitro skin penetration and permeation using emulsions as dosage forms. Drug Dev Ind Pharm 2007;33:273-80.

Tortora GJ, Derrickson B. Principles of anatomy and physiology. 11th ed. John Wiley and Sons; 2007. p. 144-70.

Ranade VV, Hollinger MA. Drug delivery system. 2nd ed. CRC Press; 2010. p. 207-27.

Gaur PK, Mishra S, Purohit S, Dave K. Transdermal drug delivery system: a review. Asian J Pharm Clin Res 2009;2:14-20.

Subramanian N, Ghosal SK, Moulik SP. Enhanced in vitro percutaneous absorption and in vivo anti-inflammatory effect of a selective cyclooxygenase inhibitor using microemulsion. Drug Dev Ind Pharm 2005;31:405-16.

Elias PM, Menon GK. Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv Lipid Res 1991;24:1-26.

Butler H. Poucher’s perfumes cosmetics and soaps. 10th ed. Springer, India; 2010. p. 402.

Bruton L, Keith P, Blumenthal D, Buxton L. Goodman and Gillman’s manual of pharmacology and therapeutics. 2nd ed. Mc Graw’s Hill; 2008. p. 1086-94.

Lachman L, Lieberman HA. The Theory and Practice of Industrial Pharmacy. 3rd ed. Varghese Publishing house; 1990. p. 534.

Vyas SP, Khar RK. Controlled drug delivery. 1st ed. Vallabh Prakashan; 2002. p. 416-7.

Bonacucina G, Cespi M, Palmieri GF. Characterization and stability of emulsion gels based on acrylamide/sodium acryloyldimethyltaurate copolymer. AAPS PharmSciTech 2009;10:368-75.

Benson HA. Transdermal drug delivery: penetration enhancement techniques. Curr Drug Delivery 2005;2:23-33.

Rutter N. Drug absorption through the skin: a mixed blessing. Arch Dis Child 1987;62:220-1.

Zhang X, Zhao R, Qian W. Preparation of an emulgel for the treatment of aphthous ulcer on the basis of carbomers. Chin Pharm J 1995;30:417-8.

Swarbrick J. Encyclopedia of Pharmaceutical Technology. 3rd ed.; 2006. p. 1551.

Gibson M. Pharmaceutical Preformulation and Formulation, Interpharm; 2004.

Mortazavi SA, Aboofazeli R. An investigation into the effect of various penetration enhancers on percutaneous absorption of piroxicam. Iranian J Pharm Res 2003;2:135-40.

Kumar L, Verma R. In vitro evaluation of topical gel prepared using natural polymer. Int J Drug Delivery 2010;2:58-63.

Jacob SW, Francone CA. Structure and function of man. WB Saunders Co. Philadelphia; 1970. p. 55-60.

Williams AC, Barry BW. Terpenes and the lipid-protein partitioning theory of skin penetration enhancement. Pharm Res 1997;8:17-24.

Ranga PM, Sellakumar V, Natarajan R, Mohan KK. Formulation and In-vitro evaluation of ciprofloxacin-loaded topical emulgel. Int J Pharm Chem Sci 2012;1:237-42.

Singla V, Saini S, Rana AC, Singh G. Development and evaluation of topical emulgel of lornoxicam using different polymer bases. Int Pharm Sci 2012;2:36-44.

Narendran H, Koorapati S, Mamidibathula L. Formulation and evaluation of aceclofenac-lycopene transemulgel. World J Pharm Res 2013;2:1036-45.

Chaudhari P, Ajab A, Malpure P, Kolsure P, Sanap D. Development and in vitro evaluation of thermoreversible nasal gel formulations of rizatriptan benzoate. Indian J Pharm Educ Res 2009;43:55-62.

Jones DS, Woolfson AD, Brown AF. Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. Int J Pharm 1997;151:223-33.




About this article

Title

EMULGEL: A NEW APPROACH FOR ENHANCED TOPICAL DRUG DELIVERY

Keywords

Emulgel, Gelling agents, Topical drug delivery, Skin diseases

DOI

10.22159/ijcpr.2017v9i1.16628

Date

31-12-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 1, 2017 Page: 15-19

Online ISSN

0975-7066

Statistics

151 Views | 933 Downloads

Authors & Affiliations

Sunil Kumar Yadav
Shambhunath Institute of Pharmacy, Jhalwa, Allahabad, Uttar Pradesh 211012, India

Manoj Kumar Mishra

Anupamaa Tiwari

Ashutosh Shukla


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