SEAWEED EXTRACTS EXHIBIT ANTICANCER ACTIVITY AGAINST HeLa CELL LINES

  • Ashwini S.
  • Suresh Babut V.
  • Saritha .
  • Manjula Shantara Shantaram Department of Studies in Biochemistry, Mangalore University, Post Graduate Centre, Chikka Aluvara, 571232, Kodagu, Karnataka, India

Abstract

Objective: This study was conducted to examine the anticancer activities in the extracts of marine seaweeds Gracilariacorticata.

Methods: The acetone, chloroform, ethanol, methanol and aqueous extracts of collected seaweeds were tested for their anticancer properties in vitro against HeLa cancer cell lines.

Results: The anticancer activity of the seaweed extracts was observed at 24hours, 48 hours and 72 h in which chloroform and ethanol extracts of G. corticata showed a greater activity with an IC50 value of 341.82 µg/ml and 244.7 µg/ml respectively for 48hours. P-values were determined by two-way analysis of variance (ANOVA). The morphology of the treated cells showed a great variation when compared to the control cells. Thus, the in vitro assay indicates that the extracts of seaweeds are the significant source of a noble anticancer agent.

Conclusion: This study also infers that G. corticata could be a potential candidate for cancer therapy in the near future.

Keywords: Seaweeds, Cytotoxicity, HeLa cell lines, Anticancer

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How to Cite
S., A., S. B. V., S. ., and M. S. Shantaram. “SEAWEED EXTRACTS EXHIBIT ANTICANCER ACTIVITY AGAINST HeLa CELL LINES”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 1, Dec. 2016, pp. 114-7, doi:10.22159/ijcpr.2017v9i1.16632.
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