A VALIDATED SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF VILAZODONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM


Nita Yadav, Anju Goyal

Abstract


Objective: In the present research work three simple, accurate, precise methods of the UV-visible spectrophotometric method was developed and validated for the estimation of Vilazodone HCl in bulk and tablet dosage.

Methods: Three methods were used for estimation of Vilazodone HCl using methanol. Method A involves zero order spectroscopy at absorption maximum of 241 nm; Method B involves first order derivative at 246.5 nm and Method C involves second-order derivative at 243.5 nm. The developed methods were validated according to ICH guidelines.

Results: The developed methods were found to be linear in the concentration range of 1-5 µg/ml. The mean percentage label claim of Vilazodone HCl was within the acceptable range. The accuracy data showed % recovery and % RSD within the range.

Conclusion: The developed methods were found to be accurate and precise. The % RSD values were within limits. These methods can be used for the routine analysis of Vilazodone HCl in bulk and tablet dosage form.


Keywords


Spectrophotometric Method, Vilazodone HCl, Validation

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About this article

Title

A VALIDATED SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF VILAZODONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM

Keywords

Spectrophotometric Method, Vilazodone HCl, Validation

DOI

10.22159/ijcpr.2017v9i1.16637

Date

31-12-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 1, 2017 Page: 132-135

Online ISSN

0975-7066

Statistics

45 Views | 78 Downloads

Authors & Affiliations

Nita Yadav
School of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, RJ.

Anju Goyal
Department of Pharmaceutical Chemistry, B. N. PG College of Pharmacy, Udaipur


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