A VALIDATED SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF VILAZODONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM

  • Nita Yadav School of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, RJ.
  • Anju Goyal Department of Pharmaceutical Chemistry, B. N. PG College of Pharmacy, Udaipur

Abstract

Objective: In the present research work three simple, accurate, precise methods of the UV-visible spectrophotometric method was developed and validated for the estimation of Vilazodone HCl in bulk and tablet dosage.

Methods: Three methods were used for estimation of Vilazodone HCl using methanol. Method A involves zero order spectroscopy at absorption maximum of 241 nm; Method B involves first order derivative at 246.5 nm and Method C involves second-order derivative at 243.5 nm. The developed methods were validated according to ICH guidelines.

Results: The developed methods were found to be linear in the concentration range of 1-5 µg/ml. The mean percentage label claim of Vilazodone HCl was within the acceptable range. The accuracy data showed % recovery and % RSD within the range.

Conclusion: The developed methods were found to be accurate and precise. The % RSD values were within limits. These methods can be used for the routine analysis of Vilazodone HCl in bulk and tablet dosage form.

Keywords: Spectrophotometric Method, Vilazodone HCl, Validation

References

1. The Online Merck Index. Maryadele J, O’ Neil. Editor 15th edn. Merck and Co, White House Station, NJ, USA; 2006.
2. http://www.drugs.com. [Last accessed on 28 Aug 2013]
3. Hughes ZA. Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. Eur J Pharma 2005;510:49-57.
4. Forest Pharmaceuticals, Inc., Viibryd (Vilazodone) Prescribing Information; 2011. Available from: http://www.frx. com/pi/viibryd pi.pdf. [Last accessed on 17 Oct 2011]
5. Ghosh S, Bomma S, Prasanna VL, Banji D. Development of a validated UV-spectrophotometric method for the Estimation of Vilazodone Hydrochloride. Int J Drug Dev Res 2014;6:169-74.
6. Srinivas B, Yadagiriswamy P, Venkateswarlu G. Spctro-photometric determination of drugs in bulk and pharmaceutical dosage form by using p-chloranilic acid. Int J Pharm Res Biol Sci 2015;4:213-28.
7. Ghosh S, Venkatesh S, Ravikumar BVV. Development of stability indicating RP-HPLC method and validation for the estimation of vilazodone hydrochloride. Int J PharmTech Res 2015;7:204-11.
8. Reddy PB, Pramod N, Venkateswararao P, Sudhakar babu AMS. Method development and validation for the assay of vilazodone in bulk and formulation by using rp-hplc technique: Int J Biol Pharma Res 2012;3:789-95.
9. Validation of Analytical Procedure Methodology. ICH Harmonized Tripartite Guidelines; 1996. p. 1-8.
10. Becket AH, Stenlake JB. Practical pharmaceutical chemistry. 4th ed. New Delhi: C. B. S. Publications; 2007. p. 243-56.
Statistics
320 Views | 830 Downloads
Citatons
How to Cite
Yadav, N., and A. Goyal. “A VALIDATED SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF VILAZODONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 1, Dec. 2016, pp. 132-5, doi:10.22159/ijcpr.2017v9i1.16637.
Section
Original Article(s)