• RIFA’ATUL MAHMUDAH Department of Pharmacy, Mandala Waluya Institute of Health Sciences, Kendari, Indonesia
  • I KETUT ADNYANA Pharmacology-Clinical Pharmacy Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia
  • NENGFISHERI KURNIA Pharmacology-Clinical Pharmacy Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia


Objective: Tamarind (Tamarindusindica L.) is one of the plants, which most of its parts are not only rich in nutrients, but also has been used widely in the community as a medicine, and one of them is believed to have effectiveness as anti-asthma.

Methods: The study of that anti-asthma activity was conducted by using the test method of improvement breathing patterns in the male guinea pig and using anti-inflammatory testing in male Wistar rats.

Results: The results of breathing patterns improvement test shows that there is no significant difference of breath intensity between observation groups (extract in doses of 25 mg/kg bw guinea pig, 75 mg/kg bw guinea pig, and 225 mg/kg bw guinea pig) and the control group. However, it has significant differences (p<0.05) in the decline of breath frequency, in line with the effect that given by methylprednisolone 4.5 mg/kg bw guinea pig and salbutamol 4 mg/kg bw guinea pig. While the result of anti-inflammatory test shows the significant decrease in inflammation percentage in each of observation group (extract in doses of 25 mg/kg bw rat, 75 mg/kg bw rat, and 225 mg/kg bw rat) than the control group at minute 30 up to 360, it is in line with the reduction effect given by methylprednisolone 4.5 mg/kg bw rat.

Conclusion: The best effect in breathing patterns improvements and anti-inflammatory are demonstrated by extract in a dose of 75 mg/kg bw. One of the anti-asthma mechanisms is an anti-inflammatory effect.

Keywords: Tamarindusindica L., Anti-asthmatic, The improvement of breathing pattern, Anti-inflammatory


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How to Cite
MAHMUDAH, R., I. K. ADNYANA, and N. KURNIA. “ANTI-ASTHMA ACTIVITY OF TAMARIND PULP EXTRACT (TAMARINDUS INDICA L.)”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 3, May 2017, pp. 102-5, doi:10.22159/ijcpr.2017.v9i3.19986.
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