ANTI-ASTHMA ACTIVITY OF TAMARIND PULP EXTRACT (TAMARINDUS INDICA L.)


Rifa’atul Mahmudah, I Ketut Adnyana, Nengfisheri Kurnia

Abstract


Objective: Tamarind (Tamarindusindica L.) is one of the plants, which most of its parts are not only rich in nutrients, but also has been used widely in the community as a medicine, and one of them is believed to have effectiveness as anti-asthma.

Methods: The study of that anti-asthma activity was conducted by using the test method of improvement breathing patterns in the male guinea pig and using anti-inflammatory testing in male Wistar rats.

Results: The results of breathing patterns improvement test shows that there is no significant difference of breath intensity between observation groups (extract in doses of 25 mg/kg bw guinea pig, 75 mg/kg bw guinea pig, and 225 mg/kg bw guinea pig) and the control group. However, it has significant differences (p<0.05) in the decline of breath frequency, in line with the effect that given by methylprednisolone 4.5 mg/kg bw guinea pig and salbutamol 4 mg/kg bw guinea pig. While the result of anti-inflammatory test shows the significant decrease in inflammation percentage in each of observation group (extract in doses of 25 mg/kg bw rat, 75 mg/kg bw rat, and 225 mg/kg bw rat) than the control group at minute 30 up to 360, it is in line with the reduction effect given by methylprednisolone 4.5 mg/kg bw rat.

Conclusion: The best effect in breathing patterns improvements and anti-inflammatory are demonstrated by extract in a dose of 75 mg/kg bw. One of the anti-asthma mechanisms is an anti-inflammatory effect.


Keywords


Tamarindusindica L., Anti-asthmatic, The improvement of breathing pattern, Anti-inflammatory

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About this article

Title

ANTI-ASTHMA ACTIVITY OF TAMARIND PULP EXTRACT (TAMARINDUS INDICA L.)

Keywords

Tamarindusindica L., Anti-asthmatic, The improvement of breathing pattern, Anti-inflammatory

DOI

10.22159/ijcpr.2017.v9i3.19986

Date

05-05-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 3, 2017 Page: 102-105

Online ISSN

0975-7066

Statistics

153 Views | 72 Downloads

Authors & Affiliations

Rifa’atul Mahmudah

I Ketut Adnyana

Nengfisheri Kurnia


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