EFFECTIVE MANAGEMENT OF ODONTOGENIC INFECTIONS THROUGH CONTROLLED FASHION BY POLYMERIC DEVICE CONTAINING MOXYFLOXACIN
Objective: Present work demonstrates the use of film that releases the drug at a pre-programmed manner. Several methods have been explored for management of moxifloxacin in dealing of Odontogenic infections which are mainly caused by necrotic pulp or by bacterial invasion from the periodontal tissue. These are usually mixed bacterial infections, and they penetrate mostly into the soft and bony oromaxillofacial tissues to produce submucosal infiltrates and abscesses.
Methods: The films were developed with the intention to minimize the dose of a drug, to deliver definite concentration and to preserve dosage at its site for a longer period by this means gets a better patient compliance. Moxifloxacin films were prepared by solvent casting technique using gellan gumÂ at different concentrations and PEG 400 as plasticizers. Compatibility study such as FT-IR and DSC also performed to check the interaction between drug and excipients used. The formulations were evaluated for their thickness, weight uniformity, folding endurance, content uniformity, surface pH, In vitro drug release. Optimized formulations were subjected to in vitro antibacterial activity and stability studies to assess the effectiveness of the formulations.
Results: Formulations shown the good uniformity of drug content, there was no any kind of effect on moisture loss test. Weight and thickness of the films were found to be uniform. Plasticizer like PEG400 was found to influence their effect on drug release as well as characteristics of films.
Conclusion: In vitro studies revealed that the formulations provide the best alternative to prolong drug release at the end of 10 h and formulations remained stable with intact at ambient conditions.
2. Frydman WL, Abbaszadeh K. Diagnosis and management of odontogenic oral and facial infections. Oral Health 2014;1. http://www.oralhealthgroup.com
3. Bresco-Salinas M, Costa-Riu N, Berini-Aytes L, Gay-Escoda C. Antibiotic susceptibility of the bacteria causing odontogenic infections. Med Oral Patol Oral Cir Bucal 2006;11:e70â€“5.
4. Poveda Roda R, Bagan JV, Sanchis Bielsa JM, Carbonell Pastor E. Antibiotic use in dental practice: a review. Med Oral Patol Oral Cir Bucal 2007;12:e186â€“92.
5. Granizo JJ, GimÃ©nez MJ, Bascones A, Aguilar L. Ecological impact of treatment of odontologic infections. Rev Esp Quimioter 2006;19:14â€“20.
6. Robert P, Holmes C, Barzani G, Sebastiani FR. Antimicrobial therapy and surgical management of odontogenic infections. A Textbook of Advanced Oral and Maxillofacial Surgery. Vol. 3. Book edited by Mohammad Hosein Kalantar Motamedi, Chapter 1; 2016.
7. Brook I, Frazier EH, Gher ME. Aerobic and anaerobic microbiology of periapical abscess. Oral Microbiol Immunol 1991;6:123-5.
8. Gordon JM, Walker CB. Current status of systemic antibiotic usage in destructive periodontal disease. J Periodontal 1993;64:760-71.
9. Pandit JK. Targeted devices for periodontal disease. In: N K Jain. Ed. Controlled and novel drug delivery. CBS Publishers and distributors, New Delhi, India; 2004. p. 130.
10. Gorle AP, Gattani SG. Design and evaluation of polymeric ocular drug delivery system. Chem Pharm Bull 2009:57:914-9.
11. Manoj Kumar, Prabhushankar GL, Satheshbabu PR. Formulation and in vitro evaluation of periodontal films containing metronidazole. Int J PharmTech Res 2010;2:2188-93.
12. Gorle A, Sadeque M. Formulation and characterization of transdermal film containing ondansetron hydrochloride. J Pharm Sci Innovation 2016;5:125-30.
13. Mohammed Gulzar Ahmed, Narayana Charyulu, Kanthraj, Harish N, Prabhakar Prabhu. Preparation and evaluation of periodontal strips of gatifloxacin for periodontal diseases. Int J Pharma Biol Sci 2010;1:1-8.
14. Mastiholimath, Danddagi, Gadad AK, Patil MB, Chandur VK. Formulation and evaluation of ornidazole dental implants for periodontitis. Indian J Pharma Sci 2006;68:71.
15. Gorle AP, Patil M. Formulation and evaluation of transdermal drug delivery system containing lornoxicam. Res J Pharm Biol Chem Sci 2016;7:21-48.
16. Nair SC, Anoop KR. Design and in vitro evaluation of controlled release satranidazole subgingival films for periodontitis therapy. Int J Pharm Sci Rev Res 2014;24:8-14.
17. Vineetha VC, Mathews MM. Development and evaluation ff dental films containing an antibacterial agent for the treatment of periodontitis. Int J Pharm Pharm Sci 2014;7:52-9.
18. Gorle AP, Gattani SG. Development and evaluation of ocular drug delivery system. Pharm Dev Technol 2010;15:46-52.
19. Katiyar A, Prajapati SK, Ali A, Vishwkarma SK. Formulation and evaluation of dental film for periodontitis. Int J Pharm 2012;3:143-8.
20. Sajid Ali, Javed Ali, Alka Ahuja, Sarfaraz Alam. Formulation and characterization of dental film containing ofloxacin. J Appl Pharm Sci 2012;2:114-9.
21. Hebbar S, Nayak S, Nayak Shwetha, Manja N, Shabaraya AR. Ormulation and evaluation of levofloxacin dental strips for periodontitis diseases. Am J PharmTech Res 2013;3:948-55.