DESIGN AND FABRICATION OF MEDICATED CHOCOLATE FORMULATION BY CHOCOLATE DRUG DELIVERY SYSTEM


Reddy Sunil, K. Mounika, A. Venkatesham

Abstract


Objective: The objective of this study is to design and fabricate Chlorpheniramine Maleate chocolate formulation by chocolate drug delivery system. Chlorpheniramine Maleate binds to histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of negative symptoms brought on by histamine.

Methods: Chocolate is a range of products derived from cocoa (cacao), mixed with fat (i.e., cocoa butter) and finely powdered sugar to produce a solid confectionery. The medicated chocolate formulation is widely used for pediatric administration and increases patient compliance. Chlorpheniramine Maleate chocolate formulation is prepared to improve patient compliance. Chocolates were formulated (F1-F3) with a total fat of 25-35 % (w/w) from cocoa liquor and cocoa butter with more than 34% total cocoa, composition as specified for dark chocolate, lecithin, sweetening agents.

Results: The prepared chocolate formulations were evaluated for general appearance, drug content, In vitro drug release and DSC and FTIR, moisture content and blooming tests. F1 formulation releases complete drug within 60 min.

Conclusion: The results indicate that the formulation has no drug excipient interactions and there was no degradation in drug, it is stable during chocolate formulation preparation.

 


Keywords


Chlorpheniramine Maleate, Chocolate, Medicated chocolate, In vitro drug release

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About this article

Title

DESIGN AND FABRICATION OF MEDICATED CHOCOLATE FORMULATION BY CHOCOLATE DRUG DELIVERY SYSTEM

Keywords

Chlorpheniramine Maleate, Chocolate, Medicated chocolate, In vitro drug release

DOI

10.22159/ijcpr.2017v9i5.22156

Date

21-09-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 5 (Aug-Sep), 2017 Page: 128-133

Online ISSN

0975-7066

Statistics

80 Views | 41 Downloads

Authors & Affiliations

Reddy Sunil
S. V. S. Group of Institutions, S. V. S. School of Pharmacy, Bheemaram, Warangal, Telangana State. India
India

K. Mounika
St. Peter’s College of Pharmacy, Madikonda, Kazipet, Hanamkonda. Telangana State India
India

A. Venkatesham
S. V. S. Group of Institutions, S. V. S. School of Pharmacy, Bheemaram, Warangal, Telangana State. India
India


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