PROTECTIVE EFFECT OF ACORUS CALAMUS RHIZOME IN PARACETAMOL EXPOSURE INDUCED HEPATOTOXICITY IN RATS: BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY


G. Srividya, K. Adilaxmamma, C. H. Srilatha

Abstract


Objective: To study the hepatoprotective activity of an aqueous and alcoholic extract of Acorus calamus rhizomes against the paracetamol induced hepatotoxicity in rats.

Methods: Hepatotoxicity was induced by oral administration of paracetamol and chemical parameters such as Glutathione peroxidase, Glutathione reductase, Glutathione, Catalase, lipid peroxidation and histopathological changes in liver was studied by comparing with Silymarin, a standard hepatoprotective drug.

Results: Treatment of rats with aqueous and alcoholic extract of Acoruscalamus rhizome after paracetamol administration normalized the altered levels of above parameters which may comparable with Silymarin and Vit-E. The hepatoprotective activity was confirmed by histopathological examination of the liver tissue of control and treated animals.

Conclusion: Based on the result it can be concluded that Acorus calamus rhizome possesses hepatoprotective effect against paracetamol-induced hepatotoxicity in rats.


Keywords


Acorus calamus rhizome, Paracetamol, Silymarin, Vit-E, Hepatoprotection

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About this article

Title

PROTECTIVE EFFECT OF ACORUS CALAMUS RHIZOME IN PARACETAMOL EXPOSURE INDUCED HEPATOTOXICITY IN RATS: BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY

Keywords

Acorus calamus rhizome, Paracetamol, Silymarin, Vit-E, Hepatoprotection

DOI

10.22159/ijcpr.2018v10i3.27218

Date

17-05-2018

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 10, Issue 3 (May-June), 2018 Page: 7-10

Online ISSN

0975-7066

Authors & Affiliations

G. Srividya
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Tirupati, Andhrapradesh

K. Adilaxmamma
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Tirupati, Andhrapradesh

C. H. Srilatha
Department of Veterinary Pathology, College of Veterinary Science Tirupati, Andhrapradesh


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