NANOPLEX: A REVIEW OF NANOTECHNOLOGY APPROACH FOR SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT


Poonam Madhukar Kasar, Kalyani Sundarrao Kale, Dipti Ganesh Phadtare

Abstract


The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. Nanoplex means drug nanoparticle complex with the oppositely charged polyelectrolyte. In this technique, the cationic or anionic drug is reacted with an oppositely charged polyelectrolyte to form a complex. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. The nanoplex formed shows improved solubility and dissolution rate compared to raw drug crystals. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene-drug delivery, drug delivery to the brain and protein and peptide drug delivery.

Keywords


Nanotechnology, Nanoplex, Polyelectrolyte, Solubility enhancement, Dissolution

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About this article

Title

NANOPLEX: A REVIEW OF NANOTECHNOLOGY APPROACH FOR SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT

Keywords

Nanotechnology, Nanoplex, Polyelectrolyte, Solubility enhancement, Dissolution

DOI

10.22159/ijcpr.2018v10i4.28467

Date

16-07-2018

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 10, Issue 4 (July-Aug), 2018 Page: 6-10

Online ISSN

0975-7066

Authors & Affiliations

Poonam Madhukar Kasar
R. G. S Institute of Pharmacy, Anjaneri, Nashik, Maharashtra, India

Kalyani Sundarrao Kale
R. G. S Institute of Pharmacy, Anjaneri, Nashik, Maharashtra, India

Dipti Ganesh Phadtare
R. G. S Institute of Pharmacy, Anjaneri, Nashik, Maharashtra, India


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