• ALI ESMAIL AL-SNAFI Department of Pharmacology, College of Medicine, Thi qar University, Iraq


Lawsonia inermis (Family: Lythraceae) contained carbohydrates, phenolic, flavonoids, saponins, proteins, alkaloids, terpenoids, quinones, coumarins, xanthones, fat, resin and tannins. It also contained 2-hydroxy-1,4-naphthoquinone (lawsone). Many alkaloids, naphthoquinone derivatives, phenolics and flavonoids were isolated from different parts of Lawsonia inermis. The pharmacological studies showed that Lawsonia inermis showed antibacterial, antifungal, antiparasitic, molluscicidal, antioxidant, hepatoprotective, central nervous, analgesic, anti-inflammatory, antipyretic, wound and burn healing, immunomodulatory, antiurolithiatic, antidiabetic, hypolipidemic, antiulcer, antidiarrhoeal, diuretic, anticancer and many other pharmacological effects. The current review will highlight the chemical constituents and pharmacological effects of Lawsonia inermis.

Keywords: Lawsonia inermis, Constituents, Pharmacology, Napthoquinone, Lawsone


1. Al-Snafi AE. Chemical constituents and pharmacological activities of milfoil (Achillea santolina)-a review. Int J Pharm Tech Res 2013;5:1373-7.
2. Al-Snafi AE. The Pharmaceutical importance of Althaea officinalis and Althaea rosea: a review. Int J Pharm Tech Res 2013;5:1387-5.
3. Al-Snafi AE. The pharmacology of Anchusa italica and Anchusa strigosa-a review. Int J Pharm Pharm Sci 2014;6:7-10.
4. Al-Snafi AE. The pharmacological importance of Anethum graveolens-a review. Int J Pharm Pharm Sci 2014;6:11-3.
5. Al-Snafi AE. The chemical constituents and pharmacological importance of Carthamus tinctorius-an overview. J Pharm Biol 2015;5:143-66.
6. Al-Snafi AE. The chemical constituents and pharmacological importance of Chrozophora tinctoria. Int J Pharm Rev Res 2015;5:391-6.
7. Al-Snafi AE. The pharmacology of Crocus sativus-a review. IOSR J Pharm 2016;6:8-38.
8. Al-Snafi AE. The medical importance of Cydonia oblonga-a review. IOSR J Pharm 2016;6:87-99.
9. Al-Snafi AE. Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)-a review. IOSR J Pharm 2017;7:7-20.
10. Al-Snafi AE. Glycyrrhiza glabra: a phytochemical and pharmacological review. IOSR J Pharm 2018;8:1-17.
11. Al-Snafi AE. Chemical constituents and pharmacological activities of Gossypium herbaceum and Gossypium hirsutum-a review. IOSR J Pharm 2018;8:64-80.
12. Al-Snafi AE. Chemical constituents and pharmacological effect of Inula graveolens (Syn: Dittrichia graveolens)-a review. Indo Am J Pharm Sci 2018;5:2183-90.
13. Al-Snafi AE. Chemical constituents, nutritional, pharmacological and therapeutic importance of Juglans regia-a review. IOSR J Pharm 2018;8:1-21.
14. Al-Snafi AE. Medical importance of Juniperus communis-a review. Indo Am J Pharm Sci 2018;5:1792-979.
15. Al-Snafi AE. Pharmacological and therapeutic importance of Hibiscus sabdariffa-a review. Int J Pharm Res 2018;10:451-75.
16. The plant list, a working list of all plant species, Lawsonia inermis. Available from: http://www.theplantlist.org/tpl/record/kew-2353863. [Last accessed on 08 Apr 2019]
17. ITIS report, Lawsonia inermis. Available from: https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSNandsearch_value=503345#null. [Last accessed on 08 Apr 2019]
18. U. S. National Plant Germplasm System, Lawsonia inermis. Available from: https://npgsweb.ars-grin.gov/gringlobal/ taxonomydetail.aspx?21699. [Last accessed on 08 Apr 2019]
19. Boubaya A, Marzougui N, Ben Yahia L, Ferchichi A. Chemical diversity analysis of Tunisian Lawsonia inermis L. populations. Afr J Biotechnol 2011;10:4980-87.
20. Zumrutdal E, Ozaslan M. A miracle plant for the herbal pharmacy; henna (Lawsonia inermis). Pharmacology 2012;896:483-9.
21. Afzal M, Al-Oriquat, Al-Hussan JM, Mohammed N. Flavone glycosides from Lawsonia inermis. Heterocycle 1980;14:1973-6.
22. Jain VC, Shah DP, Sonani NG, Dhakara S, Patel NM. Pharmacognostic and preliminary phytochemical investigation of Lawsonia inermis L leaf. Rom J Biol Plant Boil 2010;55:127-33.
23. Trease GE, Evans WC. Pharmacognosy. 14th ed. London: Saunders Company Ltd; 1996. p. 246-98.
24. Shastry CS, Kiran UP, Aswathanarayana BJ. Effect of acute and chronic administration of the aqueous extract of Lawsonia inermis leaves on haloperidol induced catalepsy in albino mice. Res J Pharm Biol Chem Sci 2012;3:1107-16.
25. Borade AS, Kale BN, Shete RV. A phytopharmacological review on Lawsonia inermis (Linn). Int J Pharm Life Sci 2011;2:536-41.
26. Mahmoud ZF, Abdel Salam NA, Khafagy SM. Constituents of henna leaves-Lawsonia inermis L growing in egypt. Fitoterapia 1980;51:153-5.
27. Nakhala AM, Zakin N, Mahrous TS, Ghali M, Youssef AM. Isolation and identification of four aromatic compounds from henna leaves. Chem Microbial Technol Lebenson 1980;6:103-5.
28. Afzal M, Al-Oriqual G, Al-Hussan JM, Mohammed N. Isolation of 1,2-dihydroxy-4-glucosyloxynaphthalene from Lawsonia inermis. Heterocycle 1984;22:813-6.
29. Dzhuraev KS, Nuraliev YN, Kurbanov M, Akhmedova LF, Abyshev AZ. Leaf coumarins of Lawsonia inermis grown in tadzhikistan. Rastit Resur 1982;18:377-9.
30. Sharma RK, Goel A, Bhatia AK. Antityphoid activity and phytochemical screening of different extracts of L. inermis plant leaves. Int J Curr Res 2016;8:37539-42.
31. Oda Y, Nakashima S, Kondo E, Nakamura S, Yano M, Kubota C, et al. Comparison of lawsone contents among Lawsonia inermis plant parts and neurite outgrowth accelerators from branches. J Nat Med 2018;72:890-6.
32. Babili FE, Bouajila J, Valentin A, Chatelain C. Lawsonia inermis: Its anatomy and its antimalarial, antioxidant and human breast cancer cells MCF7 activities. Pharm Anal Acta 2013;1:203.
33. Dhouafli Z, Ben Jannet H, Mahjoub B, Leri M, Guillard J, Saidani Tounsi M, et al. 1,2,4-trihydroxynaphthalene-2-O-?-D-glucopyranoside: a new powerful antioxidant and inhibitor of A?42 aggregation isolated from the leaves of Lawsonia inermis. Nat Prod Res 2017;29:1-9.
34. Yang CS, Chen JJ, Huang HC, Huang GJ, Wang SY, Sung PJ, et al. New benzenoid derivatives and other constituents from Lawsonia inermis with inhibitory activity against NO production. Molecules 2017;22:936-44.
35. Jacob PP, Saral AM. Two harmala alkaloids from Lawsonia inermis seeds. Chem Nat Compd 2013;49:780.
36. Hien DT, Huong TT, Cuong NX, Thao NP, Nam NH, Dat NT, et al. Triterpenoid constituents from Lawsonia inermis. J Sci Technol 2010;78A:22-6.
37. Kidanemariam TK, Tesama TK, Asressu KH, Boru AD. Chemical investigation of Lawsonia inermis L leaves from Afar Region, Ethiopia. Oriental J Chem 2013;29:1129-34.
38. Oyedeji OA, Ekundayo O, Koenig WA. Essential oil composition of Lawsonia inermis L. leaves from Nigeria. J Essent Oil Res 2005;17:403-4.
39. Rahmat A, Edrini S, Ismail P, Yap Yun Hin T, Abu Bakar MF. Chemical constituents, antioxidant activity and cytotoxic effects of essential oil from Stobilan thescrispus and Lawsonia innernis. J Biol Sci 2006;6:1005-10.
40. Najar B, Pistelli L. Essential oil composition of Lawsonia inermis leaves from Tunisia. Am J Essential Oils Nat Prod 2017;5:7-11.
41. Hasan KM, Yesmin S, Akhter SF, Paul S, Sarker S, Islam A, et al. Hepatoprotective potentiality of various fractions of ethanolic extracts of Lawsonia Inermis (henna) leaves against chemical-induced hepatitis in rats. Biochem Mol Biol 2016;1:17-22.
42. Chaibi R, Drine S, Ferchichi A. Chemical study and biological activities of various extracts from Lawsonia inermis (Henna) seeds. Acta Medica Mediterranea 2017;33:981-6.
43. Jafarzadeh L, Seifi N, Shahinfard N, Sedighi M, Kheiri S, Shirzad H, et al. Antioxidant activity and teratogenicity evaluation of Lawsonia inermis in BALB/c mice. J Clin Diagnostic Res 2015;9:1-4.
44. Takeda Y, Fatope MO. New phenolic glucosides from Lawsonia inermis. J Nat Prod 1988;51:725-9.
45. Cuong NX, Nhiem NX, Thao NP, Nam NH, Dat NT, Anh Hle T, et al. Inhibitors of osteoclastogenesis from Lawsonia inermis leaves. Bioorg Med Chem Lett 2010;20:4782-4.
46. Rajeswari J, Rani S. Isolation, structural elucidation of flavonoid constituents from Lawsonia inermis linn. Der Pharm Lett 2016;8:79-84.
47. Cuong NX, Thao NP, Nam NH, Dat NT, Anh HT, Huong LM, et al. Flavonoid constituents from Lawsonia inermis. J Sci Technol 2010;78A:27-30.
48. Yang CS, Chen JJ, Huang HC, Huang Gj, Wang SY, Chao LK, et al. New flavone and eudesmane derivatives from Lawsonia inermis and their inhibitory activity against NO production. Phytochem Lett 2017;21:123-7.
49. Iqbal K, Iqbal J, Staerk D, Kongstad KT. Characterization of antileishmanial compounds from Lawsonia inermis L. leaves using semi-high resolution antileishmanial profiling combined with HPLC-HRMS-SPE-NMR. Front Pharmacol 2017;8:337.
50. Bhardwaj DK, Murari R, Seshadri TR, Singh R. Lacoumarin from Lawsonia inermis. Phytochemistry 1976;15:1789.
51. Yang CS, Huang HC, Wang SY, Sung PJ, Huang GJ, Chen JJ, et al. New diphenol and isocoumarins from the aerial part of Lawsonia inermis and their inhibitory activities against NO production. Molecules 2016;21:E1299.
52. Sharma RK, Goel A. Identification of phytoconstituents in Lawsonia inermis Linn. leaves extract by GC-MS and their antibacterial potential. Pharmacogn J 2018;10:1101-8.
53. Wagini NH, Soliman AS, Abbas MS, Hanafy YA, El-Saady MB. Phytochemical analysis of Nigerian and Egyptian henna (Lawsonia inermis L) leaves using TLC, FTIR and GCMS. Plant 2014;2:27-32.
54. Mengoni T, Peregrina DV, Censi R, Cortese M, Ricciutelli M, Maggia F, et al. SPME-GC-MS analysis of commercial henna samples (Lawsonia inermis L). Nat Prod Res: Formerly Nat Prod Lett 2015;30:268-75.
55. Yusuf M. Phytochemical analysis and antibacterial studies of Lawsonia inermis leaves extract. J Chem Pharm Res 2016;8:571-5.
56. Bich DH, Chung DQ, Chuong BX, Dong NT, Dam DT, Hien PV, et al. Medicinal plants and animals of vietnam. Hanoi Sci Technol Publisher 2004;II:130-3.
57. Al-Saimary I. Antistaphylococcal activity of henna extracts Lawsonia inermis L (Lythraceae). J Microbiol 2015;1:8-11.
58. Akter A, Neela A, Khan MSI, Islam S, Alam F. Screening of ethanol, petroleum ether and chloroform extracts of medicinal plants, Lawsonia inermis L and Mimosa pudica L for antibacterial activity. Indian J Pharm Sci 2010;72:388-92.
59. Muhammad HS, Muhammad S. The use of Lawsonia inermis linn (henna) in the management of burn wound infections. Afr J Biotechnol 2005;4:934-7.
60. Aicha L, Rachid D, Abed A. Antibacterial activity and anti-biofilm formation of henna (Lawsonia inermis) extracts against Pseudomonas aeruginosa. J Appl Environ Biol Sci 2017;7:92-104.
61. Kannahi M, VinothaInt K. Antimicrobial activity of Lawsonia inermis leaf extracts against some human pathogens. J Curr Microbiol Appl Sci 2013;2:342-9.
62. Yang JY, Lee HS. Antimicrobial activities of active component isolated from Lawsonia inermis leaves and structure-activity relationships of its analogues against food-borne bacteria. J Food Sci Technol 2015;52:2446-51.
63. Wadekar JB, Pawar PY, Nimbalkar VV, Honde BS, Jadhav PR, Nale SB. Anticonvulsant, anthelmintic and antibacterial activity of Lawsonia inermis. J Phytopharmacol 2016;5:53-5.
64. Al-Rubiay KK, Jaber NN, Al-Mhaawe BH, Alrubaiy LK. Antimicrobial efficacy of henna extracts. Oman Med J 2008;23:253-6.
65. Al-Daamy AAK, Abdul Hassan A, Mahmood A. Study of antibacterial activity of Lawsonia inermis leaf extract. J Contemp Med Sci 2016;2:103-6.
66. Habbal OA, Al-Jabri AA, El-Hag AH, Al-Mahrooqi ZH, Al-Hashmi A. In vitro antimicrobial activity of Lawsonia inermis linn (henna). A pilot study of omani henna. Saudi Med J 2005;26:69-72.
67. Musa AE, Selv AT, Vindhan RA, Madhan B, Fathima A, Rao JR, et al. Evaluation of antimicrobial activity of Lawsonia inermis (henna) against microbial strains isolated from goat skin/leather. JALCA 2011;106:170-5.
68. Malekadeh F. Antimicrobial activity of Lawsonia inermis L. Appl Microbiol 1968;16:663-4.
69. Bhuvaneswari K, Poongothai SG, Kuruvilla A, Appala Raju B. Inhibitory concentrations of Lawsonia inermis dry powder for urinary pathogens. Indian J Pharmacol 2002;34:260-3.
70. Arun P. In vitro antibacterial activity of Lawsonia inermis (henna) leaves. PhD thesis, Educational and Research Institute University, Chennai; 2010.
71. Saadabi MAA. Evaluation of Lawsonia inermis linn. (Sudanese henna) leaf extracts as an antimicrobial agent. Res J Biol Sci 2007;2:419-23.
72. Habbal O, SHasson S, AHl-Hag AH, Al-Mahrooqi Z, Al-Hashmi N, Al-Bimani Z, et al. Antibacterial activity of Lawsonia inermis linn (henna) against Pseudomonas aeruginosa. Asian Pac J Trop Biomed 2011;1:173-6.
73. Sarojini N, Kanti CC, Manjari SA, Kumari SU, Priyanka J. In vitro antibacterial activities of Lawsonia inermis leaf extracts. Int Res J Pharm 2012;3:195-7.
74. Abdul Hamza B, ALzubedy H, Omar S, Al-hamdany M, Kwater R, Al-Kazaly M, et al. Biological effect of Lawsonia inermis plant. Al-Mustansiriyah J Sci 2016;27:1-5.
75. Al-Mehna BMM, Kadhum EAH. Effect of Lawsonia inermis extract on the pathological changes of skin infection by Streptococcus pyogens in lab mice. Al-Qadisiya J Vet Med Sci 2011;10:45-53.
76. Jeyaseelan EC, Jenothiny S, Pathmanathan MK, Jeyadevan JP. Antibacterial activity of sequentially extracted organic solvent extracts of fruits, flowers and leaves of Lawsonia inermis L from Jaffna. Asian Pac J Trop Biomed 2012;2:798-802.
77. Elmanama AA, Alyazji AA, Abu Gheneima NA. Antibacterial, antifungal and synergistic effect of Lawsonia inermis, Punica granatum and Hibiscus sabdariffa. Annals of Alquds Med 2011;7:33-41.
78. Sujanamulk B, Chintamaneni R, Chennupati A, Nahar P, Chaluvadi RS, Vemugunta R, et al. Evaluation of antifungal efficacy of ethanolic crude lawsone and listerine mouthwash in onc ontrolled diabetics and denture wearers-a randomized clinical trial. J Clin Diagn Res 2016;10:ZC90-95.
79. Mudi SY, Ibrahim H, Bala MS. Acute toxicity studies of the aqueous root extract of Lawsonia inermis linn in rats. J Med Plant Res 2011;35:5123-6.
80. Mardani M, Badiee P, Gharibnavaz M, Jassebi A, Jafarian H, Ghassemi F. Comparison of anti-candida activities of the ancient plants Lawsonia inermis and Ziziphus spinachristi with antifungal drugs in Candida species isolated from oral cavity. J Conserv Dent 2018;21:359-62.
81. Ravichandran S, Muthuraman S. Examining the anti-candidal activity of 10 selected Indian herbs and investigating the effect of Lawsonia inermis extract on germ tube formation, protease, phospholipase, and aspartate dehydrogenase enzyme activity in Candida albicans. Indian J Pharmacol 2016;48:47-52.
82. Yaralizadeh M, Abedi P, Namjoyan F, Fatahinia M, Nezamiv, Chegini S. A comparison of the effects of Lawsonia inermis (Iranian henna) and clotrimazole on Candida albicans in rats. J Mycol Med 2018;28:419-23.
83. Gozubuyuk GS, Aktas E, Yigit N. An ancient plant Lawsonia inermis (henna): Determination of in vitro antifungal activity against dermatophytes species. J Mycol Med 2014;24:313-8.
84. Sharma KK, Saikia R, Kotoky, Kalita JC, Devi R. Antifungal activity of Solanum melongena L, Lawsonia inermis L, Justicia gendarussa B against dermatophytes. Int J PharmTech Res 2011;3:1635-40.
85. Rahmoun N, Boucherit Otmani Z, Boucherit K, Benabdallah M, Choukchou-Braham N. Antifungal activity of the Algerian Lawsonia inermis (henna). Pharm Biol 2013;51:131-5.
86. Singla S, Gupta R, Puri A, Singh V, Roy S. Comparison of anticandidal activity of Punica granatum (pomegranate) and Lawsonia inermis (henna leaves): an in vitro study. Int J Dental Res 2013;1:8-13.
87. Ismail KA, Ibrahim AN, Ahmed MA, Hetta MH. Comparison between the effect of Lawsonia inermis and flubendazole on Strongyloides species using scanning electron microscopy. J Parasit Dis 2016;40:415-22.
88. Singh DK, Cheema HS, Saxena A, Jyotshana Singh S, Darokar MP, Bawankule DU, et al. Fraxetin and ethyl acetate extract from Lawsonia inermis L ameliorate oxidative stress in P. berghei infected mice by augmenting antioxidant defence system. Phytomedicine 2017;36:262-72.
89. Al-Ogaili N. Synergistic effect of Lawsonia inermis and Peganum harmala aqueous extracts on in vitro growth of Leishmania tropica promastigotes comparison to sodium stibogluconate. Al-Qadisiyah Med J 2016;12:76-83.
90. Motazedian MH, Mikaeili F, Mohebali M, Miri R, Habibi P, Kamarloie S. The antileishmanial effects of Lawsonia inermis and Cedrus libani on Leishmania major promastigotes: an in vitro study. J Parasit Dis 2017;41:375-9.
91. Serakta M, Djerrou Z, Mansour Djaalab H, Kahlouche Riachi F, Hamimed S, Trifa W, et al. Antileishmanial activity of some plants growing in Algeria: Juglans regia, Lawsonia inermis and Salvia officinalis. Afr J Tradit Complement Altern Med 2013;10:427-30.
92. Anna T, Harikrishnan TJ, Meenakshisundaram A, Arunachalam K, Suriya K, Narendran RR. Anticoccidial effects of Lawsonia inermis against caecal coccidiosis in broilers. 2016;2:246.
93. Wurochekke AU, Chechet G, Nok AJ. In vitro and in vivo anti trypanosomal activity of the leaf of Lawsonia inermis against Trypanosoma brucei infection in mice. J Medical Sci 2004;4:236-9.
94. Tauheed AM, Shittu SH, Suleiman MM, Habibu B, Kawu MU, Kobo PI, et al. In vivo ameliorative effects of methanol leaf extract of Lawsonia inermis linn on experimental Trypanosoma congolense infection in wistar rats. Int J Vet Sci Med 2016;4:33-40.
95. Marimuthu S, Rahuman AA, Santhoshkumar T, Jayaseelan C, Kirthi AV, Bagavan A, et al. Lousicidal activity of synthesized silver nanoparticles using Lawsonia inermis leaf aqueous extract against pediculus humanus capitis and bovicola ovis. Parasitol Res 2012;111:2023-33.
96. Bakhshi H, Abai MR, Amin G, Zolfi R, Pirmohammadi M, Bakhshi A, et al. Larvicidal properties of botanical extracts of Lawsonia inermis against Anopheles stephensi. Adv Infect Dis 2014;4:178-85.
97. Khanavi M, Vatandoost H, Khosravi Dehaghi N, Sanei Dehkordi A, Sedaghat MM, Hadjiakhoondi A, et al. Larvicidal activities of some Iranian native plants against the main malaria vector, Anopheles stephensi. Acta Med Iran 2013;51:141-7.
98. Singh A, Singh DK. Molluscicidal activity of Lawsonia inermis and its binary and tertiary combinations with other plant derived molluscicides. Indian J Exp Biol 2001;39:263-8.
99. Kumar M, Chandel M, Kaur P, Pandit K, Kaur V, Kaur S, et al. Chemical composition and inhibitory effects of water extract of henna leaves on reactive oxygen species, DNA scission and proliferation of cancer cells. EXCLI J 2016;15:842-57.
100. Hossain MA. In vitro determination of antioxidant capacity for methanolic extract of Eichhornia crassipes, Lawsonia inermis L and Cissus quadrangularis L By DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging assay. Bachelor thesis, East West University, Dhaka; 2008.
101. Hasan KM, Yesmin S, Akhter SF, Paul S, Sarker S, Islam A, et al. Hepatoprotective potentiality of various fractions of ethanolic extracts of Lawsonia inermis (henna) leaves against chemical-induced hepatitis in rats. Biochem Mol Biol 2016;1:17-22.
102. Philip Jacob P, Madhumitha G, Mary Saral A. Free radical scavenging and reducing power of Lawsonia inermis L seeds. Asian Pac J Trop Med 2011;4:457-61.
103. Kumar M, Kaur P, Chandel M, Singh AP, Jain A, Kaur S. Antioxidant and hepatoprotective potential of Lawsonia inermis L leaves against 2-acetyl amino fluorene induced hepatic damage in male wistar rats. BMC Complement Altern Med 2017;17:56.
104. Mohamed MA, Eldin IM, Mohammed AE, Hassan HM. Effects of Lawsonia inermis L. (henna) leaves' methanolic extract on carbon tetrachloride-induced hepatotoxicity in rats. J Intercult Ethnopharmacol 2015;5:22-6.
105. Darvin SS, Esakkimuthu S, Toppo E, Balakrishna K, Paulraj MG, Pandikumar P, et al. Hepatoprotective effect of lawsone on rifampicin-isoniazid induced hepatotoxicity in in vitro and in vivo models. Environ Toxicol Pharmacol 2018;61:87-94.
106. Latha PG, Suja SR, Shyamala S, Rajasekharan S. Some hepatoprotective garden plants. Nat Prod Radiance 2005;4:278-9.
107. Anand KK, Singh B, Chand D, Chandan BK. An evaluation of Lawsonia alba extract as hepatoprotective agent. Planta Med 1992;58:22-5.
108. Hsouna AB, Mongi S, Culioli G, Blache Y, Ghlissi Z, Chaabane R, et al. Protective effects of ethyl acetate fraction of Lawsonia inermis fruits extract against carbon tetrachloride-induced oxidative damage in rat liver. Toxicol Ind Health 2016;32:694-706.
109. Ahmed S, Saeed A, Asadullah M. Effectiveness of Lawsonia inermis for psychopharmacological activity on staircase in NMRI mice. Med Forum 2016;27:2-4.
110. Ahmed S, Iqbal J. Aniolytic effect of Lawsonia inermis (henna) on light dark boxactivity. World J Pharm Pharm Sci 2014;3:1334-9.
111. Pal SC, Kasture VS, Kasture SB. Effect of Lawsonia inermis on memory and behavior mediated via monoamine neurotransmitters. Indian J Pharmacol 1998;30:181-5.
112. Ali BH, Bashir AK, Tanira MO. Anti-inflammatory, antipyretic, and analgesic effects of Lawsonia inermis L (henna) in rats. Pharmacology 1995;51:356-63.
113. Imam H, Mahbub NU, Khan MF, Hana HK, Sarker MM. Alpha amylase enzyme inhibitory and anti-inflammatory effect of Lawsonia inermis. Pak J Biol Sci 2013;16:1796-800.
114. Ramya A, Vijayakumar N, Renuka M. Antiarthritic effect of Lawsonia inermis L an in vitro study. Int J Modn Res Revs 205;3:744-7.
115. Ziaei A, Sahranavard S, Gharagozlou MJ, Faizi M. Preliminary investigation of the effects of topical mixture of Lawsonia inermis L and Ricinus communis L leaves extract in treatment of osteoarthritis using MIA model in rats. Daru 2016;24:12.
116. Manivannan R, Aeganathan R. Analgesic activity of Lawsonia inermis leaves extract in swiss albino mice. Pharm Biol Evaluations 2016;3:360-5.
117. Kumari P, Singh N, Kumar D. Synergistic analgesic activity of chloroform extract of Lawsonia inermis linn and Chlorophytum borivilianum sant. J Pharm Phytochem 2015;3:35-8.
118. Sultana S, Khosru KH. Analgesic and antidiarrhoeal activity of Lawsonia inermis. Int J Pharma Sci Res 2011;2:3183-8.
119. Nayak BS, Isitor G, Davis EM, Pillai GK. The evidence based wound healing activity of Lawsonia inermis linn. Phytother Res 2007;21:827-31.
120. Galehdari H, Negahdari S, Kesmati M, Rezaie A, Shariati G. Effect of the herbal mixture composed of Aloe vera, henna, Adiantum capillus-veneris, and myrrha on wound healing in streptozotocin-induced diabetic rats. BMC Complement Altern Med 2016;16:386.
121. Mutluoglu M, Uzun G. Can henna prevent ulceration in diabetic feet at high risk? Hindawi Publishing Corporation Experimental Diabetes Research; 2009. http://dx.doi.org/10.1155/2009/ 107496.
122. Hadisi Z, Nourmohammadi J, Nassiri SM. The antibacterial and anti-inflammatory investigation of Lawsonia inermis-gelatin-starch nano-fibrous dressing in burn wound. Int J Biol Macromol 2018;107(Pt B):2008-19.
123. Sakarkar DM, Sakarkar UM, Shrikhande VN, Purohit RN. Wound healing properties of henna leaves. Nat Prod Radiance 2004;3:406-12.
124. Hekmatpou D, Ahmadian F, Eghbali M, Farsaei S. Henna (Lawsonia inermis) as an inexpensive method to prevent decubitus ulcers in critical care units: a randomized clinical trial. J Evid Based Integr Med 2018;23:2515690 X18772807. DOI:10.1177/2515690X18772807.
125. Esteki R, Miraj S. The abortificient effects of hydroalcoholic extract of Lawsonia inermis on BALB/c mice. Electronic Physician 2016;8:2568-75.
126. Aguwa CN. Toxic Effects of the methanolic extract of Lawsonia inermis roots. Pharm Biol 1987;25:241-5.
127. Mikhaeil BR, Badria FA, Maatooq GT, Amer MMA. Antioxidant and immunomodulatory constituents of henna leaves. Zeitschrift Fuer Naturforschung Section C J Biosci 2004;59:468-76.
128. Dikshit V, Dikshit J, Saraf M, Thakur V, Sainis K. Immunomodulatory activity of naphthoquinone fraction of Lawsonia inermis linn. Phytomedicine (Jena) 2000;7:102-3.
129. Zubardiah L, Sudiono J. Effectiveness of Lawsonia inermis L leaves methanol extracts on gingivitis healing (In vivo study on sprague dawley rats). Br J Med Med Res 2016;15:1-8.
130. Zubardiah L, Mustaqimah DN, Auerkari EI. Effectiveness of Lawsonia inermis linneaus leaves infusion in gingivitis healing. Dentika Dental J 2012;17:105.
131. Patel KM, Shah SK. Evaluation of antiurolithiatic activity of Lawsonia inermis in rats. Int J Pharma Sci Nanotec 2017;10:3728-35.
132. Kore KJ, Shete RV, Jadhav PJ, Kabra MP. Antiurolithiatic effects of hydroalcoholic extract of Lawsonia inermis L leaves. Int J Universal Pharm Life Sci 2011;1:81-95.
133. Singh S, Verma N, Karwasra R, Kalra P, Kumar R, Gupta YK. Safety and efficacy of hydroalcoholic extract from Lawsonia inermis leaves on lipid profile in alloxan-induced diabetic rats. Ayu 2015;36:107-12.
134. Antika MA, Ilyas SA, Sari MI. Effect of Lawsonia inermis linn ethanol extract on the superoxide dismutase activity in hyperglycemic Rattus norvegicus. Indonesian J Med 2017;2:79-85.
135. Arayne MS, Sultana N, Mirza AZ, Zuberi MH, Siddiqui FA. In vitro hypoglycemic activity of methanolic extract of some indigenous plants. Pak J Pharm Sci 2007;20:268-73.
136. Abdillah S, Budiady I, Winarno H. Hypoglycaemic and anti-hyperlipidemic effects of henna leaves extract (Lawsonia inermis linn) on alloxan induced diabetic mice. Jordan J Pharm Sci 2008;1:126-31.
137. Goswami M, Kulshreshtha M, Rao CV, Yadav S, Yadav S. Anti-ulcer potential of Lawsonia inermis L leaves against gastric ulcers in rats. J Appl Pharm Sci 2011;1:69-72.
138. Candra KRY, Sandya LSD, Ruth SK, Nagarjuna S, Padmanabha RY. Evaluation of diuretic activity of aqueous and ethanolic extracts of Lawsonia inermis leaves in rats. Asian J Plant Sci Res 2011;1:28-33.
139. Pradhan R, Dandawate P, Vyas A, Padhye S, Biersack B, Schobert R, et al. From body art to anticancer activities: perspectives on medicinal properties of henna. Curr Drug Targets 2012;13:1777-98.
140. da Silva AJ, Buarque CD, Brito FV, Aurelian L, Macedo LF, Malkas LH, et al. Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol. Bioorg Med Chem 2002;10:2731-8.
141. Kemp AJ, Lyons SD, Christopherson RI. Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells. J Biol Chem 1986;261:14891-5.
142. Kamei H, Koide T, Kojima T, Hashimoto Y, Hasegawa M. Inhibition of cell growth in culture by quinones. Cancer Biother Radio Pharm 1998;13:185-8.
143. Abdel Hamid NM, Mohafez OM, Nazmy MH, Farhan A, Thabet K. The effect of co-administration of Lawsonia inermis extract and octreotide on experimental hepatocellular carcinoma. Environ Health Prev Med 2015;20:195-203.
144. Li Q, Gao W, Cao J, Bi X, Chen G, Zhang X, et al. New cytotoxic compounds from flowers of Lawsonia inermis L. Fitoterapia 2014;94:148-54.
145. Ozaslan M, Zumrutdal ME, Daglioglu K, Kilic IH, Karagoz ID. Antitumoral effect of Lawsonia inermis in mice with EAC. Int J Pharmacol 2009;5:263-7.
146. Zumrutdal ME, Ozaslan M, Tuzcu M, Kalender ME, Dagl?oglu K. Effect of Lawsonia inermis treatment on mice with sarcoma. Afr J Biotechnol 2008;7:2781-6.
147. Priya R, Ilavenil S, Kaleeswaran B, Srigopalram S, Ravikumar S. Effect of Lawsonia inermis on tumor expression induced by dalton's lymphoma ascites in swiss albino mice. Saudi J Biol Sci 2011;18:353-9.
148. Endrini S, Rahmat A, Ismail P, Taufiq-Yap YH. Comparing of the cytotoxicity properties and mechanism of Lawsonia inermis and Strobilanthes crispus extract against several cancer cell lines. J Med Sci 2007;7:1098-102.
149. Endrini S, Rahmat A, Ismail P, Taufiq Yap YH, Othman F. Effects of henna (Lawsonia inermis) on the apoptotic pathway of human liver carcinoma cell lines. J Appl Sci Res 2011;7:321-6.
150. Dasgupta T, Rao AR, Yadava PK. Modulatory effect of henna leaf (Lawsonia inermis) on drug metabolising phase I and phase II enzymes, antioxidant enzymes, lipid peroxidation and chemically induced skin and forestomach papillomagenesis in mice. Mol Cell Biochem 2003;245:11-22.
151. Kapadia GJ, Rao GS, Sridhar R, Ichiishi E, Takasaki M, Suzuki N, et al. Chemoprevention of skin cancer: effect of Lawsonia inermis L (henna) leaf powder and its pigment artifact, lawsone in the epstein-barr virus early antigen activation assay and in two-stage mouse skin carcinogenesis models. Anticancer Agents Med Chem 2013;13:1500-7.
152. Nakashima S, Oda Y, Nakamura S, Liu J, Onishi K, Kawabata M, et al. Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (henna). Bioorg Med Chem Lett 2015;25:2702-6.
153. Ong CY, Ling SK, Ali RM, Chee CF, Samah ZA, Ho AS, et al. Systematic analysis of in vitro photocytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy. J Photochem Photobiol B Biol 2009;96:216-22.
154. Yogisha S, Samiulla DS, Prashanth D, Padmaja R, Amit A. Trypsin inhibitory activity of Lawsonia inermis. Fitoterapia 2002;73:690-1.
155. Abdelgadir EH, Ahmed RH, Adam SI, Husein AM. Evaluation of toxicological activity (acute and sub-chronic toxicities) of the aqueous extract of Lawsonia inermis seeds on wistar rats. J Pharmacol Toxicol 2010;5:324-33.
156. Scientific Committee on Consumer Safety, SCCS. Lawsonia inermis (henna). SCCS/1511/13, 19 09; 2013.
157. Singh VK, Pandey DK. Fungitoxic studies on bark extract of Lawsonia inermis against ringworm fungi. Hindustan Antibiot Bull 1989;31:32-5.
158. Agabna NME, Shaddad SAI, Mudathir AK. Safety of Lawsonia inermis ethanolic seeds extract. J Pharm Biomed Sci 2014;04:303-9.
159. Khine YY. Acute kidney injury following Ingestion of henna leaf extract: a case report from Myanmar. Blood Purif 2017;44 Suppl 1:41-5.
67 Views | 72 Downloads
How to Cite
AL-SNAFI, A. E. “A REVIEW ON LAWSONIA INERMIS: A POTENTIAL MEDICINAL PLANT”. International Journal of Current Pharmaceutical Research, Vol. 11, no. 5, Sept. 2019, pp. 1-13, doi:10.22159/ijcpr.2019v11i5.35695.
Review Article(s)