• SUJIT NAYEK Department of Pharmaceutics, Acharya and BM Reddy College of Pharmacy, Soldevanahalli, Hesaraghatta Road, Bangalore 560107, Karnataka, India
  • ABHIRAMI VENKATACHALAM Department of Pharmaceutics, Acharya and BM Reddy College of Pharmacy, Soldevanahalli, Hesaraghatta Road, Bangalore 560107, Karnataka, India
  • SANGEETA CHOUDHURY Department of Pharmaceutics, Acharya and BM Reddy College of Pharmacy, Soldevanahalli, Hesaraghatta Road, Bangalore 560107, Karnataka, India



Nanocochleates, Cancer therapy, Cochleate, Phosphatidylserine, Cationic drug


Nanocochleates are at the forefront of the fast-growing nanotechnology sector in the delivery of drugs for cancer. This nanotechnology is the use of the cationic and anionic encapsulated drug that has poor oral bioavailability. Nanocochleate is a lipid-based drug delivery in the liposomal vesicles that is converted by calcium divalent cation into nanocochleate. Nanocochleates technology use encapsulations of the anticancer agent, which have low solubility, oral bioavailability and low permeability. This paper shows and provides an overview of the benefits of nanocochleates, drug delivery mechanism, choice of prevalent components (Phospholipids and Cations), various ways of producing nanocochleates and nanocochleate stability. Nanocochleates have far fewer constraints than other traditional carriers. To characterize nanocochleates, the suitable analytical methods are required. Therefore, in the therapy of cancer, nanocochleate becomes commonly applied and more prospective drug delivery system.


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1. Mei L, Zhang Z, Zhao L, Huang L, Yang XL, Tang J, et al. Pharmaceutical nanotechnology for oral delivery of anticancer drugs. Adv Drug Delivery Rev 2012;65:880-90.
2. Cancer statistics report worldwide. World Health Organization Web. Available from: [Last accessed on 24 Aug 2019]
3. Cancer Facts Figures. American cancer society. Available from: [Last accessed 24 Aug 2019]
4. Cancer statistics report in India. Cancer India. Available from: [Last accessed on 15 Sep 2019]
5. Feynman RP. There's plenty of room at the bottom. Eng Sci 1960;23:22–36.
6. Freitas RA. The future of nanofabrication and molecular-scale devices in nanomedicine. Stud Health Technol Inform 2002;80:45–59.
7. Kim B, Rutka JT, Chan WC. Nanomedicine. N Engl Med 2010;363:2434–43.
8. Feng SS, Zhao L, Tang J. Nanomedicine for oral chemotherapy. Nanomed 2011;6:407-10.
9. Pawar AY, Jadhav KR, Sonkamble NB, Kale MR. Nanocochleate: a novel drug delivery system. Asian J Pharm 2016;10:S234-42.
10. Bothiraja C, Rajput N, Poudel I, Rajalakshmi S, Panda B, Pawar A. Development of novel biofunctionalized chitosan decorated nanocochleates as a cancer-targeted drug delivery platform. Artif Cell Nanomed B 2018;25:1-15.
11. Pawar A, Bothiraja C, Shaikh K, Mali A. An Insight into cochleates, a potential drug delivery system. RSC Adv 2015;5:81180-202.
12. Yeale SE, Chadhari P. A review on nanocochleate-a novel lipid-based drug delivery system. J Biomed Pharm Res 2013;2:539-55.
13. Wicki A, Witzigmann D, Balasubramanian V, Huwyler J. Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. J Controlled Release 2015;200:138–57.
14. Harke B, Kulkarni A, Allorkar N. Nanocochleate: a new cornucopia in oral drug delivery. Int J Innov Pharm Sci 2013;2:1-9.
15. Bhosale R, Ghodake PP, Mane AN, Ghadge AA. Nanocochleates: a novel carrier for drug transfer. J Sci Innov Res 2013;2:964-9.
16. Vijeta P, Vivek M, Panwar AS, Darwhekar GN, Jain DK. Nanocochleate: as drug delivery vehicle. Int J Pharm Biol Sci 2011;1:31-8.
17. Anantharaman NV, Udhumansha U, Rathnam G. Optimization of cytarabine loaded nanocochleates for targeting leukemia by response surface methodology. Int J Res Pharmacol Pharmacother 2018;7:205-21.
18. Elsayed M, Abdallah OY, Naggar VF, Khalafallah NM. Lipid vesicles for skin delivery of drugs: reviewing three decades of research. Int J Pharm 2007;332:1-16.
19. Zarif L, Jin T, Segarra I, Mannino RJ. Hydrogel isolated cochleate formulations, the process of preparation and their use for the delivery of biologically relevant molecules. U. S. Patent 6592894B1; 2003.
20. Mannino RJ, Chanki M, Feketeova E, Scolpino AJ, Wang Z, Kheriri MT, et al. Targeting immune response induction with cochleate and liposome-based vaccines. Adv Drug Delivery Rev 1998;32:273?87.
21. Sonwane SA, Chavan MJ, Hase DP, Chumbhale DS, Ambare AS, Bodakhe T. Preparation, characterization and in vitro anticancer testing of quercetin-loaded nanocochleates. Pharm Res 2017;1-7.
22. Jin T, Zarif L, Mannino R. Nanocochleate formulations, the process of preparation and method of delivery of pharmaceutical agents. U. S. Patent 6153217A; 2000.
23. Poudel I, Ahiwale R, Pawar A, Mahadik K, Bothiraja C. Development of novel biotinylated chitosan-decorated docetaxel-loaded nanocochleates for breast cancer targeting. Artif Cells Nanomed Biotechnol 2018;46:229-40.
24. Zarif L. Elongated supramolecular assemblies in drug delivery. J Controlled Release 2002;81:7-23.
25. Sankar VR, Reddy YD. Nanocochleate-a new approach in lipid drug delivery. Int J Pharm Pharm Sci 2010;2:220-3.
26. Souto EB. SLN and NLC for topical delivery of antifungals [dissertation]. Free University of Berlin; 2005.
27. Delmarre D, Lu R, Tatton N, Krause ES, Gould Fogerite S, Mannino R. Formulation of hydrophobic drugs into cochleate delivery vehicles: a simplified protocol and formulation kit. Drug Delivery Technol 2004;4:64-9.
28. Landge A, Pawar A, Shaikh K. Investigation of cochleates as carriers for topical drug delivery. Int J Pharm Pharm Sci 2013;5:314-20.
29. Leila Zarif. Drug delivery by lipid cochleates. In: Duzgunes N. editor. Methods in Enzymology, Liposomes. Part E. United Kingdom: Academic Press; 2005. p. 314-29.
30. Pawar AP, Vinugala D, Bothiraja C. Nanocochleates derived from nanoliposomes for paclitaxel oral use: preparation, characterization, in vitro anticancer testing, bioavailability and biodistribution study in rats. Biomed Pharmacother 2014;1-9. Doi:10.1016/j.biopha.2014.11.014.
31. Westesen K, Siekmann B, Koch MHJ. Investigations on the physical state of lipid nanoparticles by synchrotron radiation x-ray diffraction. Int J Pharm 1993;93:189–99.
32. Gol D, Shah V. Nanocochleates: a novel approach for drug delivery. World J Pharm Res 2014;3:1920-44.



How to Cite

NAYEK, S., A. VENKATACHALAM, and S. CHOUDHURY. “RECENT NANOCOCHLEATE DRUG DELIVERY SYSTEM FOR CANCER TREATMENT: A REVIEW”. International Journal of Current Pharmaceutical Research, vol. 11, no. 6, Nov. 2019, pp. 28-32, doi:10.22159/ijcpr.2019v11i6.36359.



Review Article(s)