TRANSETHOSOMES AND ETHOSOMES FOR ENHANCED TRANSDERMAL DELIVERY OF KETOROLAC TROMETHAMINE: A COMPARATIVE ASSESSMENT
Keywords:
Ketorolac tromethamine, Transdermal delivery, Transethosomes, ethosomes, Permeation studiesAbstract
The aim of this investigation was to formulate, evaluate and compare the transdermal potential of novel vesicular carriers: transethosomes and ethosomes. Transethosomes (TELs) and ethosomes (Els) were prepared by cold method and were characterized for particle size, entrapment efficiency, transmission electron microscopy (TEM), zeta potential, elasticity measurement, in-vitro drug release, ex-vivo permeation studies and in-vivo study. Transethosomal and ethosomal formulation showed particle size of 180 ± 70 nm and134 ± 65 nm. Transethosomes showed higher drug entrapment (80.08 ± 4.5%) than ethosomes (70.79 ± 5.6%). Both the formulation showed good zeta potential indicating good stability. The elasticity of transethosomal vesicles was found to be 3-fold higher than the ethosomal vesicles. The transdermal flux of transethosomal gel was 47.43± 0.2 µg/cm2/h and was found to give 3 fold increase in release as compared to ethosomal gel which gave 2 fold higher release of 40.38 ± 2.50µg/cm2/h as compared to the hydroethanolic solution with a release of 17.333± 0.15µg/cm2/h. Hence, the results suggested transethosomes to be a more efficient carrier system as compared to ethosomes for transdermal delivery of ketorolac tromethamine.
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