SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF QUINAZOLINONE DERIVATIVES

  • P. Y. PAWAR Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Ahmednagar 414111
  • WAGHMARE SWEETI M. Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Ahmednagar 414111

Abstract

Objective: The present study aims to synthesis and evaluation of antimicrobial activity of quinazolinone derivatives.


Methods: Methyl anthranilate react with acetyl chloride in ethanol gives methyl-2 acetamido benzoate (1) which on reaction with hydrazine hydrate gives 3-amino-2 methyl 4-(3H)-quinazolinone.(2) The amino group of synthesized quinazolinone with substituted acid chloride which gives 3-Chloroacetyl amino-2-methyl-4-quinazolinone (3) which on condensation with various primary amines gives 2-(2-methyl-4-oxo-4H-quinazoline-3yl-amino)-N-substituted acetamide (4a-4j).


Results: The reaction sequence involves microwave-induced preparation of methyl-2 acetamido benzoate (1) from reaction of Methyl anthranilate react with acetyl chloride in ethanol. Further reaction with hydrazine hydrate gives 3-amino-2 methyl 4-(3H)-quinazolinone. (2) The amino group of synthesized quinazolinone with substituted acid chloride which gives 3-Chloroacetyl amino-2-methyl-4-quinazolinone (3) which on condensation with various primary amines gives 2-(2-methyl-4-oxo-4H-quinazoline-3yl-amino)-N-substituted acetamide (4a-4j).


Which were characterized by IR and 1HNMR spectral data.


Conclusion: All the synthesized compounds were screened for antimicrobial activity by Broth dilution method. Most of the derivatives showed good antimicrobial activity against Gram-Positive and Gram-negative bacteria.

Keywords: Quinazolinone, Chloroacetyl chloride, Hydrazine hydrate, Microwave irradiation, Spectral studies, Antimicrobial activity

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PAWAR, P. Y., and W. S. M. “SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF QUINAZOLINONE DERIVATIVES”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 3, May 2020, pp. 114-6, doi:10.22159/ijcpr.2020v12i3.38318.
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