SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF QUINAZOLINONE DERIVATIVES

Authors

  • P. Y. PAWAR Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Ahmednagar 414111
  • WAGHMARE SWEETI M. Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Ahmednagar 414111

DOI:

https://doi.org/10.22159/ijcpr.2020v12i3.38318

Keywords:

Quinazolinone, Chloroacetyl chloride, Hydrazine hydrate, Microwave irradiation, Spectral studies, Antimicrobial activity

Abstract

Objective: The present study aims to synthesis and evaluation of antimicrobial activity of quinazolinone derivatives.

Methods: Methyl anthranilate react with acetyl chloride in ethanol gives methyl-2 acetamido benzoate (1) which on reaction with hydrazine hydrate gives 3-amino-2 methyl 4-(3H)-quinazolinone.(2) The amino group of synthesized quinazolinone with substituted acid chloride which gives 3-Chloroacetyl amino-2-methyl-4-quinazolinone (3) which on condensation with various primary amines gives 2-(2-methyl-4-oxo-4H-quinazoline-3yl-amino)-N-substituted acetamide (4a-4j).

Results: The reaction sequence involves microwave-induced preparation of methyl-2 acetamido benzoate (1) from reaction of Methyl anthranilate react with acetyl chloride in ethanol. Further reaction with hydrazine hydrate gives 3-amino-2 methyl 4-(3H)-quinazolinone. (2) The amino group of synthesized quinazolinone with substituted acid chloride which gives 3-Chloroacetyl amino-2-methyl-4-quinazolinone (3) which on condensation with various primary amines gives 2-(2-methyl-4-oxo-4H-quinazoline-3yl-amino)-N-substituted acetamide (4a-4j).

Which were characterized by IR and 1HNMR spectral data.

Conclusion: All the synthesized compounds were screened for antimicrobial activity by Broth dilution method. Most of the derivatives showed good antimicrobial activity against Gram-Positive and Gram-negative bacteria.

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Published

15-05-2020

How to Cite

PAWAR, P. Y., and W. S. M. “SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF QUINAZOLINONE DERIVATIVES”. International Journal of Current Pharmaceutical Research, vol. 12, no. 3, May 2020, pp. 114-6, doi:10.22159/ijcpr.2020v12i3.38318.

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