PHYTOCHEMICALS IN THE TREATMENT OF ARTHRITIS: CURRENT KNOWLEDGE

  • SOURAV BHATTACHARYA Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy and A.H.S, Dr. Meghnad Saha Sarani, Bidhan Nagar, Durgapur-713206, West Bengal, India
  • SUDIP KUMAR MANDAL Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy and A.H.S, Dr. Meghnad Saha Sarani, Bidhan Nagar, Durgapur-713206, West Bengal, India
  • MD. SEMIMUL AKHTAR Shri Ram Murti Smarak College of Engineering and Technology (Pharmacy), Bareilly, Uttar Pradesh, India
  • DIPRA DASTIDER Department of Pharmaceutical Technology, Brainware University, 398-Ramkrishnapur Road, Barasat, Kolkata-700125, West Bengal, India
  • SIPRA SARKAR Department of Pharmaceutical Technology, Brainware University, 398-Ramkrishnapur Road, Barasat, Kolkata-700125, West Bengal, India
  • SANKHADIP BOSE Department of Pharmacognosy, Bengal School of Technology, Sugandha, Hooghly 712102, West Bengal, India
  • ANINDYA BOSE Department of Pharmaceutical Chemistry, Bengal College of Pharmaceutical Science and Research, Durgapur, West Bengal 713212, India
  • SANJIT MANDAL Department of Pharmaceutical Chemistry, Bengal College of Pharmaceutical Science and Research, Durgapur, West Bengal 713212, India
  • ARINDAM KOLAY Department of Pharmaceutical Chemistry, Bengal College of Pharmaceutical Science and Research, Durgapur, West Bengal 713212, India
  • DHRUBO JYOTI SEN Department of Pharmaceutical Chemistry, School of Pharmacy, Techno India University, Salt Lake City, Sector-V, EM-4, Kolkata-700091, West Bengal, India
  • ALOK KUMAR Department of Pharmaceutical Chemistry, Sachchidanand Sinha College, Aurangabad- 824101, Bihar, India
  • SUBHAM PAN Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy and A.H.S, Dr. Meghnad Saha Sarani, Bidhan Nagar, Durgapur-713206, West Bengal, India
  • ARGHYA PRAMANICK Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy and A.H.S, Dr. Meghnad Saha Sarani, Bidhan Nagar, Durgapur-713206, West Bengal, India

Abstract

The objective of the present review is to evaluate the therapeutic potential of phytochemicals against arthritis, which is asymptomatic disorder of chronic joint inflammation followed by swelling and pain. Here, we discussed about the anti-arthritic activity of many phytomolecules such as Norisoboldine, Berberine, Triptolide, Hesperidin Hesperidin, Madecassocide, Hydroxy napthoquinone, Ginsenoside, Cryptotanshinone, Kirenol, Thymoquinone, Chlorogenic acid, Curcumin, Bromelain, Andrographolide and Allicin. These compounds are able to control inflammatory responses, proinflammatory cytokines, osteoclast differentiation and to prevent bone erosion in the joints. In this article, we reviewed anti-arthritic activities of phytichemicals from 2011-2019, using various scientific websites like PubMed, Google Scholar, Science Direct etc. Till date clinical trials conducted with anti-arthritic phytomolecules are very less. Hence, more clinical trials are needed to bring plant molecules as safe and effective anti-arthritic drugs in the market, either alone or in combination with other anti-arthritic agents.

Keywords: Phytochemicals, Anti-arthritic agents, Rheumatoid arthritis, Osteoarthritis, Chronic inflammation, Autoimmune disease

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BHATTACHARYA, S., S. K. MANDAL, M. S. AKHTAR, D. DASTIDER, S. SARKAR, S. BOSE, A. BOSE, S. MANDAL, A. KOLAY, D. J. SEN, A. KUMAR, S. PAN, and A. PRAMANICK. “PHYTOCHEMICALS IN THE TREATMENT OF ARTHRITIS: CURRENT KNOWLEDGE”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 4, July 2020, pp. 1-6, doi:10.22159/ijcpr.2020v12i4.39050.
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