HYDROTROPIC SOLUBILIZATION AND LINEARITY PROFILE OF PAZOPANIB

  • SANTOSH KARAJGI Department of Pharmaceutical Quality Assurance, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur 586103
  • SHRIPAD POTADAR Department of Pharmaceutical Quality Assurance, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur 586103

Abstract

Objective: A study on the hydrotropic solubility and linearity profile of Pazopanib was carried out by using Niacinamide as the solubilizing agent as Pazopanib is poorly soluble in water.


Methods: Pazopanib was freely soluble in water when 2.8M Niacinamide was used as a solubilizing agent. Pazopanib shows an absorption maximum at 282 nm in First derivative mode of measurement using Shimazdu UV Spectrophotometer 1800 spectronic model.


Results: At the absorption maximum of 282 nm, Pazopanib shows a linear response in the range of 5μg/ml to 15μg/ml concentration.


Conclusion: The present study is useful for the aqueous solubilization and quantitative determination of Pazopanib in bulk drug and in pharmaceutical formulations thus avoiding toxic solvents.

Keywords: Pazopanib, Hydrotropic, Solubilization, Solubility Profile, Linearity profile, Quantitative Determination

References

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How to Cite
KARAJGI, S., and S. POTADAR. “HYDROTROPIC SOLUBILIZATION AND LINEARITY PROFILE OF PAZOPANIB”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 4, July 2020, pp. 66-69, doi:10.22159/ijcpr.2020v12i4.39082.
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Original Article(s)