FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING FILMS OF EBASTINE

  • TEJASVI TORGAL Goa College of Pharmacy, 18th June Road, Panaji, Goa 403001, India
  • SHWETA BORKAR Goa College of Pharmacy, 18th June Road, Panaji, Goa 403001, India
  • PRASHANT BHIDE Goa College of Pharmacy, 18th June Road, Panaji, Goa 403001, India
  • ASMITA ARONDEKAR Goa College of Pharmacy, 18th June Road, Panaji, Goa 403001, India

Abstract

Objective: To overcome the limitations of fast dissolving tablets, a novel fast dissolving film of ebastine was formulated for attaining quick onset of action, aiding in the enhancement of bioavailability favorable in severe conditions of allergies.


Methods: Films of ebastine were prepared by the solvent casting method using hydroxypropyl methylcellulose E-15, hydroxypropyl methylcellulose K-4 as a film base with different concentrations of crospovidone as superdisintegrant and polyethylene glycol-400 as a plasticizer. Further physical characteristics such as uniformity of weight, thickness, and drug content uniformity, tensile strength, folding endurance, percentage elongation, surface pH, disintegration and in vitro drug release were evaluated.


Results: The optimized formulations with film base hydroxypropyl methylcellulose E-15 and hydroxypropyl methylcellulose K-4 containing 8% crospovidone showed 99.34 % and 97.42 % of maximum cumulative percentage release respectively exhibiting first order kinetics. However, no significant change was observed in stability studies.


Conclusion: The concept of formulating fast dissolving films of ebastine offers a suitable approach in exhibiting rapid onset of action with improved delivery.

Keywords: Ebastine, Fast dissolving films, Hydroxypropyl methylcellulose, Crospovidone, In vitro dissolution studies

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TORGAL, T., S. BORKAR, P. BHIDE, and A. ARONDEKAR. “FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING FILMS OF EBASTINE”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 5, Sept. 2020, pp. 111-5, doi:10.22159/ijcpr.2020v12i5.39782.
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