• TEJASVI TORGAL Goa College of Pharmacy, 18th June Road, Panaji, Goa 403001, India
  • SHWETA BORKAR Goa College of Pharmacy, 18th June Road, Panaji, Goa 403001, India
  • PRASHANT BHIDE Goa College of Pharmacy, 18th June Road, Panaji, Goa 403001, India
  • ASMITA ARONDEKAR Goa College of Pharmacy, 18th June Road, Panaji, Goa 403001, India



Ebastine, Fast dissolving films, Hydroxypropyl methylcellulose, Crospovidone, In vitro dissolution studies


Objective: To overcome the limitations of fast dissolving tablets, a novel fast dissolving film of ebastine was formulated for attaining quick onset of action, aiding in the enhancement of bioavailability favorable in severe conditions of allergies.

Methods: Films of ebastine were prepared by the solvent casting method using hydroxypropyl methylcellulose E-15, hydroxypropyl methylcellulose K-4 as a film base with different concentrations of crospovidone as superdisintegrant and polyethylene glycol-400 as a plasticizer. Further physical characteristics such as uniformity of weight, thickness, and drug content uniformity, tensile strength, folding endurance, percentage elongation, surface pH, disintegration and in vitro drug release were evaluated.

Results: The optimized formulations with film base hydroxypropyl methylcellulose E-15 and hydroxypropyl methylcellulose K-4 containing 8% crospovidone showed 99.34 % and 97.42 % of maximum cumulative percentage release respectively exhibiting first order kinetics. However, no significant change was observed in stability studies.

Conclusion: The concept of formulating fast dissolving films of ebastine offers a suitable approach in exhibiting rapid onset of action with improved delivery.


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How to Cite

TORGAL, T., S. BORKAR, P. BHIDE, and A. ARONDEKAR. “FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING FILMS OF EBASTINE”. International Journal of Current Pharmaceutical Research, vol. 12, no. 5, Sept. 2020, pp. 111-5, doi:10.22159/ijcpr.2020v12i5.39782.



Original Article(s)