DESIGN, DEVELOPMENT AND EVALUATION OF DILTIAZEM HYDROCHLORIDE LOADED NANOSPONGES FOR ORAL DELIVERY
Keywords:Diltiazem hydrochloride, Nil, Ethyl cellulose, Poly vinyl alcohol, Scanning Electron Microscopy, UV Spectroscopy
Objective: In the current investigation,nanosponges were set up by emulsion solvent diffusion technique utilizing ethyl cellulose and β-cyclodextrin as polymers.
Methods: Diltiazem hydrochloride is taken as model medication for considering different nanosponge formulations. The similarity of different formulation segments was set up by Fourier Transform Infra-Red (FTIR) spectroscopy. Molecular size, surface morphology, entrapment efficiency and drug content of nanosponges were analyzed. Shape and surface morphology of the nanosponges were inspected utilizing scanning electron microscopy.
Results: Molecule size of formulated nanosponges was seen in the scope of 186 to 476 nm. Scanning electron microscopy uncovered the permeable, round nature of the nanosponges. The drug content of nanosponges for ethyl cellulose containing formulations was seen as in the scope of 62.25 to 85.11% and for the β-cyclodextrin containing details were seen as in the scope of 65.18-89.67%. The percentage entrapment effectiveness of nanosponges for ethyl cellulose containing formulations were seen as in the scope of 54.18 to 79.49% and for the β-cyclodextrin containing details were seen as in the scope of 58.21-83.45%. In vitro drugreleasefindings demonstrated that at 12 h ethyl cellulose containing formulations discharged the drug in the scope of 57.27-89.09% and for the β-cyclodextrin containing formulations discharged in the scope of 73.94-93.26%.
Conclusion: Sustained drugreleasefrom formulations is supported if there is an occurrence of ethyl cellulose in the formulations rather with plans containing β-cyclodextrin.
2. Yadav GV, Panchory HP. Nanosponges-a boon to the targeted drug delivery system. J Drug Delivery Ther 2013;3:151-5.
3. Rita L, Amit T, Chandrashekhar G. Current trends in ?-cyclodextrin based drug delivery systems. Int J Res Ayurveda Pharm 2011;2:1520-6.
4. Shringirishi M, Prajapati SK, Mahor A, Alok S, Yadav P, Verma A. Nanosponges: a potential nanocarrier for novel drug delivery-a review. Asian Pacific J Trop Disease 2014;4:19-26.
5. Susmitha, Charanjit, Reddy VM, Naveena, Gupta VRM. Nanosponges–a concise review of emerging trends. Int J Pharm Res Biomed Anal 2014;3:1-6.
6. Challa R, Ahuja A, Ali J, Khar RK. Cyclodextrins in drug delivery: an updated review. AAPS PharmSciTech 2005;6:E329-57.
7. Khopade AJ, Jain S, Jain NK. The microsponge. East Pharm 1996;25:49-53.
8. Silpa JN, Nissankararao S, Bhimavarapu R, Sravanthi SL, Vinusha K, Renuka K. Nanosponges: a versatile drug delivery system. Int J Pharm Life Sci 2013;4:221-6.
9. Yang CY, Liao TC, Shuai HH, Shen TL, Yeh JA, Cheng CM. Micropatterning of mammalian cells on inorganic-based nanosponges. Biomaterials 2012;33:4988-97.
10. Bolmal UB, Manvi FV, Rajkumar K, Palla SS, Paladugu A, Reddy KR. Recent Advances in nanosponges as drug delivery system. Int J Pharm Sci Nanotechnol 2013;6:1934-44.
11. Sharma R, Pathak K. Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation. Pharm Dev Technol 2011;16:367-76.
12. Swaminathan S, Vavia PR, Trotta F, Cavalli R, Tumbiolo S, Bertinetti L, et al. Structural evidence of differentialforms of nanosponges of beta-cyclodextrin and its effect onsolubilization of a model drug. J Incl Phenom Macrocycl Chem 2012;76:201-11.
13. Bhowmik H, Venkatesh DN, Kuila A, Kumar KH. Nanosponges: a review. Int J Appl Pharm 2018;10:1-5.
14. Tambe RS, Battase PW, Arane PM, Palve SA, Talele SG, Chaudhari G. Review on nanosponges: as a targeted drug delivery system. Am J PharmTech Res 2015;5:215-24.
15. Subramanian SMK, Anandam S, Kannan KM, Rajappan M. Nanosponges: a novel class of drug delivery system–review. J Pharm Pharm Sci 2012;15:103-11.
16. Shankar S, Vavia PR, Francesco T, Satyen T. Formulation of betacyclodextrin based nanosponges of itraconazole. J Incl Phenom Macrocycl Chem 2007;57:89–94.
17. Nilesh J, Ruchi J, Navneet T, Brham P, Gupta, Deepak K, et al. Nanotechnology: a safe and effective drug delivery system. Asian J Phar Clin Res 2010;3:159-65.
18. Indira B, Bolisetti SS. Nanosponges: a new era in drug delivery. J Pharm Res 2012;5:5293-6.