FORMULATION AND IN VITRO EVALUATION OF CURCUMIN LOADED JACKFRUIT SEED STARCH NANOPARTICLES
Objectives: To meet the above aim the following objectives are undertaken: (1) Isolation of starch from jackfruit seeds and formulation of curcumin loaded jackfruit seed starch nanoparticles (2) In vitro evaluations of the drug loaded nanoparticles
Methods: Jackfruit seed starch nanoparticles were prepared by Nanoprecipitation technique. In this technique, jackfruit seed starch was mixed with curcumin and acetone solution using a magnetic stirrer at 600 rpm. To the above solution, water were added dropwise and stirred at room temperature until acetone was completely vaporized. Nanoparticles were separated by centrifugation at 4000 rpm after 40 min.
Results: Particle size of prepared nanoparticle formulations was found to be 371 to 411.72 nm with PDI of 0.148 to 0.356. The maximum % drug entrapment was found to be 57.34 % with formulation F5. In vitro release studies showed sustained release of drug till 12 h.
Conclusion: The prepared nanoparticles were evaluated for its particle size, drug entrapment efficiency, in vitro drug release study, and surface morphology studies by scanning electron microscopy. The results of Fourier transform infrared studies of 1:1 physical mixture of drug and excipients confirmed the absence of incompatibility. Thus, the study concludes that curcumin loaded jackfruit seed starch nanoparticles were developed successfully by nanoprecipitation, which is expected to enhance the oral bioavailability of curcumin.
2. Dustgania A, Vasheghani Farahani E, Imani M. Preparation of chitosan nanoparticles loaded by dexamethasone sodium phosphate. Iranian J Pharm Sci 2008;4:111-4.
3. Bhadra D, Bhadra S, Jain P, Jain NK. Pegnology: a review of PEG-ylated systems. Pharmazie 2002;57:5-29.
4. Tulyathan V, Tananuwong K, Songjinda P, Jaiboon N. Some physicochemical properties of jackfruit (Artocarpus heterophyllus Lam) seed flour and starch. Sci Asia 2002;28:37-41.
5. Mai Z, Chen J, He T, Hu Y, Dong X, Zhang H, et al. Electrospray biodegradable microcapsules loaded with curcumin for drug delivery systems with high bioactivity. RSC Adv 2017;7:1724-34.
6. Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z, Sahebkar A. Phytosomal curcumin: a review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother 2017;85:102-12.
7. Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The essential medicinal chemistry of curcumin: miniperspective. J Med Chem 2017;60:1620-37.
8. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharmaceutics 2007;4:807-18.
9. Zhao D, Zhao X, Zu Y, Li J, Zhang Y, Jiang R, Zhang Z. Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles. Int J Nanomed 2010;5:669.
10. Vazhacharickal PJ, Sajeshkumar NK, Mathew JJ, Albin AN. Morphological diversity of jackfruit (Artocarpus heterophyllus) varieties in Kerala. Prem Jose; 2018.
11. Chin SF, Mohd Yazid SN, Pang SC. Preparation and characterization of starch nanoparticles for controlled release of curcumin. Int J Polymer Sci 2014. https://doi.org/10.1155/2014/340121
12. Tan Y, Xu K, Li L, Liu C, Song C, Wang P. Fabrication of size-controlled starch-based nanospheres by nanoprecipitation. ACS Appl Mater Interfaces 2009;1:956-9.
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