THERAPEUTIC POTENTIAL OF PLANT-DERIVED OLIGOSTILBENES AND STILBENE GLYCOSIDES

  • SUTAPA BISWAS MAJEE Department of Pharmacy, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124, B L Saha Road, Kolkata 700053, West Bengal
  • DIPANJANA ASH Department of Pharmaceutics, BCDA College of Pharmacy and Technology, 78/1 Jessore Road (S), Hridaypur, Barasat, Kolkata 700127, West Bengal
  • DHRUTI AVLANI KLE College of Pharmacy, Bengaluru 560010
  • GOPA ROY BISWAS Department of Pharmaceutics, Guru Nanak Institute of Pharmaceutical Science and Technology, 147f, Nilgunj Road, Sahid Colony, Panihati, Kolkata 700110, West Bengal

Abstract

Stilbenoids constitute a major class of plant-derived secondary metabolites occurring in abundance across several families and are well-known for their nutritional and health-promoting benefits. Several investigations have established their therapeutic potential in the management of different types of cancer, neuroinflammation, arthritis, disorders in lipid metabolism, microbial infection etc. Studies on resveratrol monomer, oxyresveratrol, their synthetic analogs, piceatannol, pterostilbene can be found in the literature. But a collective and comprehensive review on chemistry, pharmacological effects, structure-activity relationship and pharmacokinetics of plant-derived oligostilbenes and stilbene glycosides is missing. These phytochemicals are generally characterised by poor oral bioavailability due to extensive first-pass metabolism and conjugation. The present chapter aims to fill up these lacunae and also focuses on further studies that can be performed in the future to translate these immensely potential secondary metabolites into human clinical setting from cell culture and animal studies at the preclinical level for effective therapeutic intervention of various pathological conditions.

Keywords: Bioavailability, Chemopreventive, Cytotoxicity, Neuroinflammatory, Pharmacokinetics, Oligostilbene, Resveratrol, Secondary metabolite, Stilbene glycoside and SAR

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MAJEE, S. B., D. ASH, D. AVLANI, and G. R. BISWAS. “THERAPEUTIC POTENTIAL OF PLANT-DERIVED OLIGOSTILBENES AND STILBENE GLYCOSIDES”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 6, Nov. 2020, pp. 13-19, doi:10.22159/ijcpr.2020v12i6.40297.
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