POWDER SOLUTION TECHNOLOGY REVIEW
Keywords:Liquisolid technology, Bioavailability, Dissolution enhancement, Lipophyllic drugs, Solubility
Bioavailability and Solubility are the challenges for the formulation of highly lipophilic drugs. Oral routes of administration is one of the acceptable route due to improved patient compliance and convenience. Regularly newly advanced drug candidates are lipophilic, BCS Class II and IV drugs. Among various methods to improve the solubility of these drugs, liquid-solid technology or Powdered solution technology change the liquid drug into non-sticky, dry free-flowing, rapid release powder. This technique involves mixing of insoluble drug with nonvolatile solvent, admixing of drug-loaded excipients change into loose powder. This technique enhances major challenges like bioavailability with low production cost and a simple manufacturing process.
2. Nayak AK, Panigrahi PP. Solubility enhancement ofetoricoxib by cosolvency approach. Int J Res 2012;86-93. https://doi.org/10.5402/2012/820653
3. Ruan LP, Yu BY, Fu GM, Zhu DN. Improving the solubility of ampelopsin by solid dispersions and inclusion complexes. J Pharma Biomed Res 2005;38:457-64.
4. Nighute AB, Bhise SB. Enhancement of dissolution rate of rifabutin by preparation of microcrystals using solvent changemethod. Int J PharmTech Res 2009;1:142-8.
5. Gupta PS, Sharma V, Pathak K. Melt sonocrystallized piroxicam for oral delivery: particle characterization, solidstate analysis and pharmacokinetics. Expert Opin Drug Delivery 2013;10:17-32.
6. Kumar B, Sharma V, Pathak K. Effect of meltsonocrystallization on pharmacotechnical properties of paracetamol, indomethacin and mefenamic acid characterized by dynamic laser scattering and its impact on solubility. Drug Dev Ind Pharm 2013;39:687-95.
7. Cavallari C, Abertini B, Rodriguez MG, Rodriguez L. Improved dissolution behaviour of steam-granulated piroxicam. Eur J Pharm Biopharm 2002;54:65-73.
8. Nazzal S, Khan MA. Controlled release of a self-emulsifying formulation from tablet dosage form: Stability assessment and optimization of some processing parameters. Int J Pharm 2006;315:110-21.
9. Kapsi SG, Ayres JW. Processing factors in development of solid solution formulation of itraconazole for enhancement of drug dissolution and bioavailability. Int J Pharm 2001;229:193-203.
10. Cole ET. Liquid-filled and sealed hard gelatin capsule technologies. 1st Edition. Modified Release Drug Delivery Technology; 2003. p. 177-90.
11. Cui J, Yu B, Zhao Y, Zhu W, Li H, Lou H. Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems. Int J Pharm 2009;371:148-55.
12. Lachman L, Leibermen HA, Kanig JK. The theory and practice of Industrial Pharmacy; 2002. p. 36-102, 184, 293.
13. Aulton ME. The science of dosage form design. 3rd ed.; 2008. p. 244-58.
14. Spireas S, Sadu S, Grover R. In vitro release evaluation of hydrocortisone liquisolid tablets. JPPS 1998;87:867–72.
15. Spirea S. Liquisolid systems and methods of preparing same. United State Patent 6; 2002;23:339.
16. Ali Nokhodchi, Christina M Hentzschel, Claudia S Leopold. Drug release from liquisolid systems: speed it up, slow it down. Expert Opin Drug Delivery 2011;8:191-205.
17. Banker GS, Anderson NL. Tablets. In: The theory and practice of industrial pharmacy. 3rd ed. Lachman L, Liberman HA, Kanig JL; 1987. p. 293-345.
18. Fahmy RH, Kassem MA. Enhancement of famotidine dissolution rate through liquisolid tablet formulation: in vitro and in vivo evaluation. Eur J Pharm Biopharm 2008;69:993-1003.
19. Charman SA, Charman WN. Oral modified release delivery systems. In: Rathbone MJ, Hadgraftb J, Roberts MS. Modified Release Drug Delivery Technology; 2003. p. 1-9.
20. Yadav VB, Nighute AB, Yadav AV, Bhise SB. Aceclofenac size enlargement by non-aqueous granulation with improved solubility and dissolution. APSR; 2009. p. 115-22.
21. Spireas S, Sadu S. Enhancement of prednisolone dissolution properties using liquisolidcompacts. Int J Pharm 1998;166:177-88.
22. Spireas Sanford, Bolton. Liquisolid systems and methods of preparing same, United States Patent, US 5800834; 1998.
23. Spiridon, Spieras. Liquisolid systems and methods of preparing same. United States Patent US 6423339B1; 2012.
24. Elkordy AA, Tan XN, Essa EA. Spironolactone release fromliquisolid formulations prepared with Capryol™ 90, Solutol®HS-15 and Kollicoat® SR 30 D as non-volatile liquid vehicles. Eur J Pharm Biopharm 2013;83:203–23.
25. Saeedi M, Akbari J, Morteza Semnani K. Enhancement of dissolution rate of indomethacin using liquisolidcompacts. Iran J Pharm Res 2011;10:25–34.
26. Hentzschel CM, Sakmann A, Leopold CS. Suitability of various excipients as carrier and coating materials for liquisolid compacts. Drug Dev Ind Pharm 2011;37:1200–7.
27. Javadzadeh Y, Shariati H, Movahhed Danesh E. Effectof some commercial grades of microcrystalline cellulose on flowability, compressibility, and dissolution profile of piroxicam liquisolid compacts. Drug Dev Ind Pharm 2009;35:243–51.
28. Gavali SM, Pacharane SS, Sankpal SV. Liquisolid compact: a new technique for enhancement of drug dissolution. IJRPC 2011;1:705–13.
29. Akash S Bhise, Sapana Ahirrao, Amol D Rahane, Sanjay Kshirsagar. Solubility enhancement of poorly water-soluble drugs using liquisolid technique. IJOD 2018;6:152-64.
30. Tiong N, Elkordy. Effects of liquisolid formulations on the dissolution of naproxen. Eur J Pharm Biopharm 2009;73:373-84.
31. Wankhede Navneet B, Walekar SS, Sadgir PS, Pawar SA, Ahirrao SP. Liquisolid: a novel technique for dissolution enhancement of poorly water-soluble drugs. AJPTI 2014;2:77-90.
32. Onoue S, Yamada S, Chan HK. Nanodrugs: pharmacokineticsand safety. Int J Nanomed 2014;9:1025-37.
33. R Santosh Kumar, Jampana Divija Sai. Liquisolid compacts: a review. JDDT 2019;9:880-3.
34. Vijay Sharma, Kamla Pathak. Attempts and outcomes of liquisolid technology: an updated chronological compilation of innovative ideas and adjuvants in the field J. Pharm Biomed Res 2016;2:1-21.
35. Enugula Pavani, Sheik Noman, Izhar Ahmed Syed. Liquisolid technique-based sustained release tablet of trimetazidine dihydrochloride. Drug Invent Tuday 2013;5:302-10.
36. Naveen Chella, Nataraj Narra, Tadikonda Rama Rao. Preparation and characterization of liquisolid compacts for improved dissolution of telmisartan. J Drug Delivery 2014. https://doi.org/10.1155/2014/692793
37. Vinod Valjibhai Siju, Moinuddin Soniwala, Swati Nagar. A novel technique to enhance dissolution rate of cilnidipine using liquisolid compact and wet granulation. IJPSR 2017;9:160-8.
38. Akash S. Bhise, Sapana Ahirrao, Amol D Rahane, Sanjay Kshirsagar. Solubility enhancement of poorly water soluble drugs using liquisolid technique. IJOD 2018;6:152-64.
39. Puppala Raman Kumar, Puvvada Chaitanya, Rachakonda Kalyani, Rangisetti Mahalakshmi Poojitha, Udaru Bhavani, Siddela Tirumala Rao. Formulation and evaluation of curcumin liquisolid tablets. JPI 2019;8:368-74.
40. Matthew Lam, Taravat Ghafourian, Ali Nokhodchi. Liquisolid system and liqui mass systems are not the same. AAPS PharmSciTech 2020;21:105.
41. Javadzadeh Y, Musaajrezaei L, Nokhodchi A. Liquisolid technique as a new approach to suatain propranolol hydrochloride release from tablet matrices. Int J Pharm 2008;362:102-8.
42. De Espindola B, Reilly Beringhs Anderee O, Divya Songelia. Liquisolid pellets: a pharmaceutical technology strategy to improve the dissolution rate of ritonavir. Saudi Pharm J 2019;27:702–12.
43. Lam M, Ghafourian T, Nokhodchi A. Liqui-pellet: the emerging next-generation oral dosage form which stems from liquisolidconcept in combination with pelletization technology. AAPS PharmSciTech 2019;20:231.
44. Pezzini BR, Litha Thomas, Anjali Anil. Liquisolid technology applied to pellets: evaluation of the feasibility and dissolution performance using felodipine as a model drug. Chem Eng Res Des 2016;110:62–9.