FORMULATION AND CHARACTERIZATION OF LOSARTAN LOADED SELF EMULSIFYING DRUG DELIVERY SYSTEM
Keywords:Self-emulsifying drug delivery system, Losartan, Sustained-release, TEM, In vitro release
Objective: The object of the present work was the advancement and portrayal of losartan stacked self-emulsifying drug conveyance framework for the successful administration of hypolipidemia (RSEDDS) for further developing bioavailability, to upgrade dissolvability, delays home time, give an adequate measure of medication to an objective site and supported the arrival of medication.
Methods: Self-Emulsifying Drug Delivery System was ready by the basic emulsification method. Six clumps, for example, F1 to F6 were ready by shifting the convergence of oils, surfactant, co-surfactant, and co-dissolvable and assessed for the different boundaries, for example, Optical microscopy, Assessment of self emulsification, Emulsification time, Droplet size investigation, Zeta Potential Measurement, Transmission Electron Microscopy, Viscosity Determination, Drug content, Percentage conveyance, in vitro disintegration study and solidness study. The SEDDS was upgraded and group F5 was additionally utilized.
Results: The medication content of chosen clump F5 was viewed as 97.65±1.37 %; it proposes that the technique for exemplification was powerful. As per in vitro study, around 55.13 % of the medication was delivered after 120 min which showed supported arrival of medication and there were no critical changes seen in the actual appearance, drug content, and in vitro drug release during the stability study.
Conclusion: This research presumed that the SEDDS are an expected competitor as a supported delivery drug conveyance, effectively expanding bioavailability and designated conveyance of medication.
Jain NK, Sharma SN. A textbook of professional pharmacy. 5th ed published by N. K. Jain for Vallabh Prakashan New Delhi; 2008. p. 1-11.
Sharma S, Sharma AD, Chauhan B, Sanwal R. Self emulsifying drug delivery systems: A modern approach for delivery of lipophilic drug. Ordonear Research Library. 2011;1:121-2.
Tang J, Sun J, He Z. Self-emulsifying drug delivery systems: strategy for improving oral delivery of poorly soluble drugs. Curr Drug Ther. 2007;2(1):85-93. doi: 10.2174/157488507779422400.
Tiong N, Elkordy AA. Effects of liquisolid formulations on the dissolution of naproxen. Eur J Pharm Biopharm. 2009;73(3):373-84. doi: 10.1016/j.ejpb.2009.08.002, PMID 19679184.
Hentzschel CM, Alnaief M, Smirnova I, Sakmann A, Leopold CS. Enhancement of griseofulvin release from solid-liquid compacts. Eur J Pharm Biopha. 2011;73:1-6.
Vijay KN, Ramarao T, Jayaveera KN. Liquisolid compacts: A novel approach to enhance the bioavailability of poorly soluble drugs. Int J Pharm Biol Sci. 2011;1:89-102.
Sachan R, Khatri K, Kasture SB. Self-eumlsifying drug delivery system: a novel approach for enhancement of bioavailability. Int J Pharm Tech Res. 2010;2:1738-45.
Patel NN, Rathva SR, Shah VH, Upadhyay UM. Review on self-emulsifying drug delivery system: novel approach for solubility enhancement. Int J Pharm Res Allied Sci. 2012;1:1-12.
Patel PA, Chaulang GM, Akolkotkar A, Mutha SS, Hardikar SR, Bhosale AV. Self-emulsifying drug delivery system: a review. Res J Pharm Technol. 2008;1:313-23.
Jingling T, Jin S, Fude C, Zhonggui H. Preparation of self-emulsifying drug delivery systems of Ginkgo biloba extracts and in vitro dissolution studies. Asian J Trad Med. 2006;1:1-4.
Khoo SM, Humberstone AJ, Porter CJH, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine. International Journal of Pharmaceutics. 1998;167(1-2):155-64. doi: 10.1016/S0378-5173(98)00054-4.
Naisarg DP. Self-emulsifying drug delivery system: A novel approach. Int J Curr Pharm Res. 2012;4:18-23.
Balakrishnan P, Lee BJ, Oh DH, Kim JO, Hong MJ, Jee JP. Enhanced oral bioavailability of coenzyme Q10 by a novel solid self-emulsifying drug delivery system. Int J Pharm. 2009;74:66-72.
Bhatt PP. Osmotic drug delivery systems for poorly soluble drugs, the drug delivery companies report Autumn/Winter; 2004. p. 26-9.
Kavita S, Ashu S, Singh SK, Saloni K. Self emulsifying drug delivery system: A tool in solubility enhancement of poorly soluble drugs. Indo Glob J Pharm Sci. 2012;2:313-32.
Dhomne. Formulation and evaluation of solid self-emulsifying drug delivery system for lipophyllic drugs. Int J Pharm Sci Rev Res. 2012;3:32-6.
Himani B, Seema B, Mayank Y, Vinod S, Mamta S. Self emulsifying drug delivery system: an approach to enhance bioavailability. International Journal of Pharma Res Dev. 2008;3:59-75.
Pathak CV, Gujarathi NA, Rane BR, Pawar SP. A review on self micro emulsifying drug delivery system. Int J Pharm Sci. 2013;4:3628-48.
Liang M, Davies NM, Toth I. Increasing entrapment of peptides within poly(alkyl cyanoacrylate) nanoparticles prepared from water-in-oil microemulsions by copolymerization. Int J Pharm. 2008;362(1-2):141-6. doi: 10.1016/j.ijpharm.2008.06.005, PMID 18598746.
Bachhav YG, Patravale VB. SMEDDS of glyburide: formulation, in vitro evaluation, and stability studies. AAPS PharmSciTech. 2009;10(2):482-7. doi: 10.1208/s12249-009-9234-1.
Tayal A, Jamil F, Sharma R, Sharma S. Self emulsifying drug delivery system: a review. Int Res J Pharm. 2012;3:32-6.
Sharma S, Bajaj H, Bhardwaj P, Sharma AD, Singh R. Development and characterization of self-emulsifying drug delivery system of a poorly water-soluble drug using natural oil. Acta Pol Pharm. 2012;69(4):713-7. PMID 22876615.
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