ANTI-INFLAMMATORY AND ANTI-ALLERGIC ACTIVITY OF ERUCA SATIVA SEED


Saima Hamid, Muhammad Gulfraz, Farnaz Malik, Umara Afzal, Kazi Muhammad Ashfaq, Abbas Hassan, Asif Hanif Chaudhry

Abstract


The present study has been designed to examine the Anti-allergic and Anti-inflammatory activity of various seed extracts of Eruca sativa in-vivo model. Milk induced leukocytosis and Eosinophilia in mice, formaldehyde induced paw edema was carried out against n-hexane and ethanolic extracts in albino mice dose dependent manner. Results showed that n-hexane extract at 400 mg/kg p. o significantly inhibited (p < 0.01) the blood eosinophilia, leukocyte and differential leukocyte count. These results were also comparable to those of dexamethasone, the reference drug used in this study. In the model of edema induced by formalin, n-hexane fractions at 400 mg/kg body weight reduced significantly (p < 0.01) the formation of edema induced by formalin. The results suggested that the hexane of Eruca sativa seeds possessed potent anti-inflammatory and anti allergic properties.

Keywords: Traditional medicines, Duncan’s Multiple Range Test, Green medicines, Eosinophils.

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About this article

Title

ANTI-INFLAMMATORY AND ANTI-ALLERGIC ACTIVITY OF ERUCA SATIVA SEED

Date

06-01-2015

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 7, Issue 1, 2015 Page: 71-73

Online ISSN

0975-7066

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Authors & Affiliations

Saima Hamid

Muhammad Gulfraz

Farnaz Malik

Umara Afzal

Kazi Muhammad Ashfaq

Abbas Hassan

Asif Hanif Chaudhry
Department of Chemistry, Quaid e Azam University, Islamabad. Geoscience Labs, Islamabad. Pakistan.


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